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Are We Ready for Migrastatics?

Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases

Cell Migration and Invasion Laboratory, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel
Author to whom correspondence should be addressed.
Academic Editor: Nick P.J. Brindle
Cells 2021, 10(8), 2037;
Received: 29 June 2021 / Revised: 5 August 2021 / Accepted: 6 August 2021 / Published: 9 August 2021
(This article belongs to the Special Issue Molecular, Cellular and Therapeutic Approaches to Cancer Metastasis)
Non-receptor tyrosine kinases (NRTKs) are crucial mediators of intracellular signaling and control a wide variety of processes such as cell division, morphogenesis, and motility. Aberrant NRTK-mediated tyrosine phosphorylation has been linked to various human disorders and diseases, among them cancer metastasis, to which no treatment presently exists. Invasive cancer cells leaving the primary tumor use invadopodia, feet-like structures which facilitate extracellular matrix (ECM) degradation and intravasation, to escape the primary tumor and disseminate into distant tissues and organs during metastasis. A major challenge in metastasis research is to elucidate the molecular mechanisms and signaling pathways underlying invadopodia regulation, as the general belief is that targeting these structures can potentially lead to the eradication of cancer metastasis. Non-receptor tyrosine kinases (NRTKs) play a central role in regulating invadopodia formation and function, but how they coordinate the signaling leading to these processes was not clear until recently. Here, we describe the major NRTKs that rule invadopodia and how they work in concert while keeping an accurate hierarchy to control tumor cell invasiveness and dissemination. View Full-Text
Keywords: invadopodia; non-receptor tyrosine kinases; cancer metastasis invadopodia; non-receptor tyrosine kinases; cancer metastasis
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MDPI and ACS Style

Saha, T.; Gil-Henn, H. Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases. Cells 2021, 10, 2037.

AMA Style

Saha T, Gil-Henn H. Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases. Cells. 2021; 10(8):2037.

Chicago/Turabian Style

Saha, Trishna, and Hava Gil-Henn. 2021. "Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases" Cells 10, no. 8: 2037.

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