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Cell Mechanics in Embryoid Bodies
Article

Skin under Strain: From Epithelial Model Tissues to Adult Epithelia

Forschungszentrum Jülich, Institute of Biological Information Processing, IBI-2: Mechanobiology, 52428 Jülich, Germany
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Academic Editor: Karl Matter
Cells 2021, 10(7), 1834; https://doi.org/10.3390/cells10071834
Received: 17 June 2021 / Revised: 13 July 2021 / Accepted: 16 July 2021 / Published: 20 July 2021
(This article belongs to the Special Issue Epithelial Cell Mechanics: From Physiology to Pathology)
Formation of a barrier capable of protecting tissue from external damage, chemical factors, and pathogens is one of the main functions of the epidermis. Furthermore, upon development and during aging, mechanoprotective epidermal functions change dramatically. However, comparative studies between embryonic and adult skin in comparison to skin equivalents are still scarce which is especially due to the lack of appropriate measurement systems with sufficient accuracy and long-term tissue compatibility. Our studies fill this gap by developing a combined bioreactor and tensile testing machine for biomechanical analysis of living epithelia. Based on this tissue stretcher, our data clearly show that viscoelastic and plastic deformation behavior of embryonic and adult skin differ significantly. Tissue responses to static strain compared to cyclic strain also show a clear dependence on differentiation stage. Multilayered unkeratinized epidermis equivalents, on the other hand, respond very similar to mechanical stretch as adult tissue. This mechanical similarity is even more evident after a single cycle of mechanical preconditioning. Our studies therefore suggest that skin equivalents are well suited model systems to analyze cellular interactions of epidermal cells in natural tissues. View Full-Text
Keywords: epithelia; skin; epidermis equivalent; biomimetic systems; tissue stretching; strain; mechanoadaptation; tensile test; viscoelasticity; elastin epithelia; skin; epidermis equivalent; biomimetic systems; tissue stretching; strain; mechanoadaptation; tensile test; viscoelasticity; elastin
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MDPI and ACS Style

Püllen, R.; Konrad, J.; Merkel, R.; Hoffmann, B. Skin under Strain: From Epithelial Model Tissues to Adult Epithelia. Cells 2021, 10, 1834. https://doi.org/10.3390/cells10071834

AMA Style

Püllen R, Konrad J, Merkel R, Hoffmann B. Skin under Strain: From Epithelial Model Tissues to Adult Epithelia. Cells. 2021; 10(7):1834. https://doi.org/10.3390/cells10071834

Chicago/Turabian Style

Püllen, Robin, Jens Konrad, Rudolf Merkel, and Bernd Hoffmann. 2021. "Skin under Strain: From Epithelial Model Tissues to Adult Epithelia" Cells 10, no. 7: 1834. https://doi.org/10.3390/cells10071834

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