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Review

Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases

1
Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland
2
Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich (LMU), 80336 Munich, Germany
3
DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, 80336 Munich, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally and share first author ship.
Academic Editors: Sylviane Muller and Marko Radic
Cells 2021, 10(7), 1689; https://doi.org/10.3390/cells10071689
Received: 2 June 2021 / Revised: 28 June 2021 / Accepted: 28 June 2021 / Published: 4 July 2021
(This article belongs to the Special Issue NETs in Infectious and Inflammatory Diseases)
Neutrophil extracellular traps (NETs) are web-like structures of decondensed extracellular chromatin fibers and neutrophil granule proteins released by neutrophils. NETs participate in host immune defense by entrapping pathogens. They are pro-inflammatory in function, and they act as an initiator of vascular coagulopathies by providing a platform for the attachment of various coagulatory proteins. NETs are diverse in their ability to alter physiological and pathological processes including infection and inflammation. In this review, we will summarize recent findings on the role of NETs in bacterial/viral infections associated with vascular inflammation, thrombosis, atherosclerosis and autoimmune disorders. Understanding the complex role of NETs in bridging infection and chronic inflammation as well as discussing important questions related to their contribution to pathologies outlined above may pave the way for future research on therapeutic targeting of NETs applicable to specific infections and inflammatory disorders. View Full-Text
Keywords: CVD; NETs; infection; inflammation; atherosclerosis; thrombosis; autoimmune diseases CVD; NETs; infection; inflammation; atherosclerosis; thrombosis; autoimmune diseases
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MDPI and ACS Style

Thakur, M.; Evans, B.; Schindewolf, M.; Baumgartner, I.; Döring, Y. Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases. Cells 2021, 10, 1689. https://doi.org/10.3390/cells10071689

AMA Style

Thakur M, Evans B, Schindewolf M, Baumgartner I, Döring Y. Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases. Cells. 2021; 10(7):1689. https://doi.org/10.3390/cells10071689

Chicago/Turabian Style

Thakur, Manovriti, Bryce Evans, Marc Schindewolf, Iris Baumgartner, and Yvonne Döring. 2021. "Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases" Cells 10, no. 7: 1689. https://doi.org/10.3390/cells10071689

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