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Review

Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia

1
Institut du Cerveau—Paris Brain Institute—ICM, INSERM, CNRS, APHP, Sorbonne Université, Pitié-Salpêtrière Hospital, 75013 Paris, France
2
Neurogenetics Team, EPHE, Paris Sciences Lettres Research University, 75000 Paris, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Marta Martinez-Vicente and Alexander E. Kalyuzhny
Cells 2021, 10(7), 1678; https://doi.org/10.3390/cells10071678
Received: 7 May 2021 / Revised: 26 June 2021 / Accepted: 29 June 2021 / Published: 2 July 2021
(This article belongs to the Special Issue Neurodegenerative Diseases: Updates and Challenges)
Hereditary spastic paraplegia (HSP) refers to a group of neurological disorders involving the degeneration of motor neurons. Due to their clinical and genetic heterogeneity, finding common effective therapeutics is difficult. Therefore, a better understanding of the common pathological mechanisms is necessary. The role of several HSP genes/proteins is linked to the endolysosomal and autophagic pathways, suggesting a functional convergence. Furthermore, impairment of these pathways is particularly interesting since it has been linked to other neurodegenerative diseases, which would suggest that the nervous system is particularly sensitive to the disruption of the endolysosomal and autophagic systems. In this review, we will summarize the involvement of HSP proteins in the endolysosomal and autophagic pathways in order to clarify their functioning and decipher some of the pathological mechanisms leading to HSP. View Full-Text
Keywords: spastic paraplegia; lysosomes; autophagy; endosomes spastic paraplegia; lysosomes; autophagy; endosomes
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MDPI and ACS Style

Toupenet Marchesi, L.; Leblanc, M.; Stevanin, G. Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia. Cells 2021, 10, 1678. https://doi.org/10.3390/cells10071678

AMA Style

Toupenet Marchesi L, Leblanc M, Stevanin G. Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia. Cells. 2021; 10(7):1678. https://doi.org/10.3390/cells10071678

Chicago/Turabian Style

Toupenet Marchesi, Liriopé, Marion Leblanc, and Giovanni Stevanin. 2021. "Current Knowledge of Endolysosomal and Autophagy Defects in Hereditary Spastic Paraplegia" Cells 10, no. 7: 1678. https://doi.org/10.3390/cells10071678

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