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Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom

Division of Molecular Biology, Ruđer Bošković Institute, Bijenička 54, HR-10000 Zagreb, Croatia
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Academic Editor: Francisco Rivero
Cells 2021, 10(7), 1592; https://doi.org/10.3390/cells10071592
Received: 28 May 2021 / Revised: 16 June 2021 / Accepted: 16 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Rho family of GTPases in Model Organisms and Systems)
Both Dictyostelium amoebae and mammalian cells are endowed with an elaborate actin cytoskeleton that enables them to perform a multitude of tasks essential for survival. Although these organisms diverged more than a billion years ago, their cells share the capability of chemotactic migration, large-scale endocytosis, binary division effected by actomyosin contraction, and various types of adhesions to other cells and to the extracellular environment. The composition and dynamics of the transient actin-based structures that are engaged in these processes are also astonishingly similar in these evolutionary distant organisms. The question arises whether this remarkable resemblance in the cellular motility hardware is accompanied by a similar correspondence in matching software, the signalling networks that govern the assembly of the actin cytoskeleton. Small GTPases from the Rho family play pivotal roles in the control of the actin cytoskeleton dynamics. Indicatively, Dictyostelium matches mammals in the number of these proteins. We give an overview of the Rho signalling pathways that regulate the actin dynamics in Dictyostelium and compare them with similar signalling networks in mammals. We also provide a phylogeny of Rho GTPases in Amoebozoa, which shows a variability of the Rho inventories across different clades found also in Metazoa. View Full-Text
Keywords: Rho; Rac; cell migration; cell motility; convergent evolution; Amoebozoa Rho; Rac; cell migration; cell motility; convergent evolution; Amoebozoa
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MDPI and ACS Style

Filić, V.; Mijanović, L.; Putar, D.; Talajić, A.; Ćetković, H.; Weber, I. Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells 2021, 10, 1592. https://doi.org/10.3390/cells10071592

AMA Style

Filić V, Mijanović L, Putar D, Talajić A, Ćetković H, Weber I. Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom. Cells. 2021; 10(7):1592. https://doi.org/10.3390/cells10071592

Chicago/Turabian Style

Filić, Vedrana, Lucija Mijanović, Darija Putar, Antea Talajić, Helena Ćetković, and Igor Weber. 2021. "Regulation of the Actin Cytoskeleton via Rho GTPase Signalling in Dictyostelium and Mammalian Cells: A Parallel Slalom" Cells 10, no. 7: 1592. https://doi.org/10.3390/cells10071592

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