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Multifactorial Pathogenic Processes of Retinal Ganglion Cell Degeneration in Glaucoma towards Multi-Target Strategies for Broader Treatment Effects
Article

Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
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Author to whom correspondence should be addressed.
Academic Editors: Paloma B. Liton and Stanislav I. Tomarev
Cells 2021, 10(6), 1398; https://doi.org/10.3390/cells10061398
Received: 19 April 2021 / Revised: 24 May 2021 / Accepted: 3 June 2021 / Published: 5 June 2021
As in glaucoma and other optic neuropathies cellular dysfunction often precedes cell death, the assessment of retinal ganglion cell (RGC) function represents a key outcome measure for neuroprotective strategies aimed at targeting distressed but still viable cells. RGC dysfunction can be assessed with the pattern electroretinogram (PERG), a sensitive measure of electrical activity of RGCs that is recorded non-invasively in human subjects and mouse models. Here, we offer a conceptual framework based on an intuitive state-transition model used for disease management in patients to identify progressive, potentially reversible stages of RGC dysfunction leading to cell death in mouse models of glaucoma and other optic neuropathies. We provide mathematical equations to describe state-transitions with a set of modifiable parameters that alter the time course and severity of state-transitions, which can be used for hypothesis testing and fitting experimental PERG data. PERG dynamics as a function of physiological stimuli are also used to differentiate phenotypic and altered RGC response dynamics, to assess susceptibility to stressors and to assess reversible dysfunction upon pharmacological treatment. View Full-Text
Keywords: retinal ganglion cell function; pattern electroretinogram; glaucoma; optic neuropathy retinal ganglion cell function; pattern electroretinogram; glaucoma; optic neuropathy
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MDPI and ACS Style

Porciatti, V.; Chou, T.-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells 2021, 10, 1398. https://doi.org/10.3390/cells10061398

AMA Style

Porciatti V, Chou T-H. Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies. Cells. 2021; 10(6):1398. https://doi.org/10.3390/cells10061398

Chicago/Turabian Style

Porciatti, Vittorio, and Tsung-Han Chou. 2021. "Modeling Retinal Ganglion Cell Dysfunction in Optic Neuropathies" Cells 10, no. 6: 1398. https://doi.org/10.3390/cells10061398

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