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Complex Roles of Neutrophils during Arboviral Infections

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900, USA
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Author to whom correspondence should be addressed.
Academic Editors: Thomas Hoenen and Allison Groseth
Cells 2021, 10(6), 1324; https://doi.org/10.3390/cells10061324
Received: 30 March 2021 / Revised: 21 May 2021 / Accepted: 21 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Virus — Host Cell Interactions)
Arboviruses are known to cause large-scale epidemics in many parts of the world. These arthropod-borne viruses are a large group consisting of viruses from a wide range of families. The ability of their vector to enhance viral pathogenesis and transmission makes the development of treatments against these viruses challenging. Neutrophils are generally the first leukocytes to be recruited to a site of infection, playing a major role in regulating inflammation and, as a result, viral replication and dissemination. However, the underlying mechanisms through which neutrophils control the progression of inflammation and disease remain to be fully understood. In this review, we highlight the major findings from recent years regarding the role of neutrophils during arboviral infections. We discuss the complex nature of neutrophils in mediating not only protection, but also augmenting disease pathology. Better understanding of neutrophil pathways involved in effective protection against arboviral infections can help identify potential targets for therapeutics. View Full-Text
Keywords: neutrophils; arboviruses; mosquito; inflammation; pathology neutrophils; arboviruses; mosquito; inflammation; pathology
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MDPI and ACS Style

Muralidharan, A.; Reid, S.P. Complex Roles of Neutrophils during Arboviral Infections. Cells 2021, 10, 1324. https://doi.org/10.3390/cells10061324

AMA Style

Muralidharan A, Reid SP. Complex Roles of Neutrophils during Arboviral Infections. Cells. 2021; 10(6):1324. https://doi.org/10.3390/cells10061324

Chicago/Turabian Style

Muralidharan, Abenaya, and St P. Reid 2021. "Complex Roles of Neutrophils during Arboviral Infections" Cells 10, no. 6: 1324. https://doi.org/10.3390/cells10061324

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