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Sirtuin 1 and Skin: Implications in Intrinsic and Extrinsic Aging—A Systematic Review

Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging

Laboratory of Bioinformatics and Computational Biology, Division of Experimental and Translational Research, Brazilian National Cancer Institute (INCA), Rio de Janeiro 20231-050, Brazil
Genomic Sciences and Biotechnology Program, Catholic University of Brasilia, Brasilia 70790-160, Brazil
Faculty of Medicine, University of Brasilia, Brasilia 70910-900, Brazil
Experimental Medicine Research Cluster (EMRC), University of Campinas (UNICAMP), Campinas 13083-970, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Taranjit Singh Rai
Cells 2021, 10(6), 1323;
Received: 26 April 2021 / Revised: 22 May 2021 / Accepted: 22 May 2021 / Published: 26 May 2021
The skin is our largest organ and the outermost protective barrier. Its aging reflects both intrinsic and extrinsic processes resulting from the constant insults it is exposed to. Aging in the skin is accompanied by specific epigenetic modifications, accumulation of senescent cells, reduced cellular proliferation/tissue renewal, altered extracellular matrix, and a proinflammatory environment favoring undesirable conditions, including disease onset. Macrophages (Mφ) are the most abundant immune cell type in the skin and comprise a group of heterogeneous and plastic cells that are key for skin homeostasis and host defense. However, they have also been implicated in orchestrating chronic inflammation during aging. Since Mφ are related to innate and adaptive immunity, it is possible that age-modified skin Mφ promote adaptive immunity exacerbation and exhaustion, favoring the emergence of proinflammatory pathologies, such as skin cancer. In this review, we will highlight recent findings pertaining to the effects of aging hallmarks over Mφ, supporting the recognition of such cell types as a driving force in skin inflammaging and age-related diseases. We will also present recent research targeting Mφ as potential therapeutic interventions in inflammatory skin disorders and cancer. View Full-Text
Keywords: immunosenescence; age-associated diseases; aging immunosenescence; age-associated diseases; aging
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MDPI and ACS Style

Guimarães, G.R.; Almeida, P.P.; de Oliveira Santos, L.; Rodrigues, L.P.; de Carvalho, J.L.; Boroni, M. Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging. Cells 2021, 10, 1323.

AMA Style

Guimarães GR, Almeida PP, de Oliveira Santos L, Rodrigues LP, de Carvalho JL, Boroni M. Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging. Cells. 2021; 10(6):1323.

Chicago/Turabian Style

Guimarães, Gabriela R., Palloma P. Almeida, Leandro de Oliveira Santos, Leane P. Rodrigues, Juliana L. de Carvalho, and Mariana Boroni. 2021. "Hallmarks of Aging in Macrophages: Consequences to Skin Inflammaging" Cells 10, no. 6: 1323.

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