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Article

Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis

1
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Roma, Italy
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Department of Neurosciences, Section of Neurology, Università Cattolica del Sacro Cuore, 00168 Roma, Italy
3
Neuroimmunology and Neuromuscular Diseases Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133 Milano, Italy
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Department of Neurosciences, University of Padova, 35122 Padova, Italy
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Department of Clinical and Experimental Sciences, University of Brescia, NeMO-Brescia Clinical Center for Neuromuscular Diseases, 25121 Brescia, Italy
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Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, Italy
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Department of Neuroscience, Mental Health and Sensory Organs (NESMOS), School of Medicine and Psychology, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, Italy
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IRCCS Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy
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Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, Italy
10
Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Deschenes
Cells 2021, 10(5), 1146; https://doi.org/10.3390/cells10051146
Received: 16 February 2021 / Revised: 3 May 2021 / Accepted: 5 May 2021 / Published: 10 May 2021
In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a commercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia. View Full-Text
Keywords: inclusion body myositis; anti-cN1A antibodies; inflammatory myopathies; autoantibodies inclusion body myositis; anti-cN1A antibodies; inflammatory myopathies; autoantibodies
MDPI and ACS Style

Lucchini, M.; Maggi, L.; Pegoraro, E.; Filosto, M.; Rodolico, C.; Antonini, G.; Garibaldi, M.; Valentino, M.L.; Siciliano, G.; Tasca, G.; De Arcangelis, V.; De Fino, C.; Mirabella, M. Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis. Cells 2021, 10, 1146. https://doi.org/10.3390/cells10051146

AMA Style

Lucchini M, Maggi L, Pegoraro E, Filosto M, Rodolico C, Antonini G, Garibaldi M, Valentino ML, Siciliano G, Tasca G, De Arcangelis V, De Fino C, Mirabella M. Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis. Cells. 2021; 10(5):1146. https://doi.org/10.3390/cells10051146

Chicago/Turabian Style

Lucchini, Matteo, Lorenzo Maggi, Elena Pegoraro, Massimiliano Filosto, Carmelo Rodolico, Giovanni Antonini, Matteo Garibaldi, Maria L. Valentino, Gabriele Siciliano, Giorgio Tasca, Valeria De Arcangelis, Chiara De Fino, and Massimiliano Mirabella. 2021. "Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis" Cells 10, no. 5: 1146. https://doi.org/10.3390/cells10051146

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