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Volume 10
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10.3390/cells10040851
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Review

Quantitative Methodologies to Dissect Immune Cell Mechanobiology

by
Veronika Pfannenstill
1,
Aurélien Barbotin
1,
Huw Colin-York
1,* and
Marco Fritzsche
1,2,*
1
Kennedy Institute for Rheumatology, University of Oxford, Roosevelt Drive, Oxford OX3 7LF, UK
2
Rosalind Franklin Institute, Harwell Campus, Didcot OX11 0FA, UK
*
Authors to whom correspondence should be addressed.
Cells 2021, 10(4), 851; https://doi.org/10.3390/cells10040851
Submission received: 28 February 2021 / Revised: 2 April 2021 / Accepted: 6 April 2021 / Published: 9 April 2021
(This article belongs to the Special Issue Molecular Mechanisms of Early T Cell Signaling)
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Abstract

Mechanobiology seeks to understand how cells integrate their biomechanics into their function and behavior. Unravelling the mechanisms underlying these mechanobiological processes is particularly important for immune cells in the context of the dynamic and complex tissue microenvironment. However, it remains largely unknown how cellular mechanical force generation and mechanical properties are regulated and integrated by immune cells, primarily due to a profound lack of technologies with sufficient sensitivity to quantify immune cell mechanics. In this review, we discuss the biological significance of mechanics for immune cells across length and time scales, and highlight several experimental methodologies for quantifying the mechanics of immune cells. Finally, we discuss the importance of quantifying the appropriate mechanical readout to accelerate insights into the mechanobiology of the immune response.
Keywords: mechanobiology; biomechanics; force; immune response; quantitative technology mechanobiology; biomechanics; force; immune response; quantitative technology

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MDPI and ACS Style

Pfannenstill, V.; Barbotin, A.; Colin-York, H.; Fritzsche, M. Quantitative Methodologies to Dissect Immune Cell Mechanobiology. Cells 2021, 10, 851. https://doi.org/10.3390/cells10040851

AMA Style

Pfannenstill V, Barbotin A, Colin-York H, Fritzsche M. Quantitative Methodologies to Dissect Immune Cell Mechanobiology. Cells. 2021; 10(4):851. https://doi.org/10.3390/cells10040851

Chicago/Turabian Style

Pfannenstill, Veronika, Aurélien Barbotin, Huw Colin-York, and Marco Fritzsche. 2021. "Quantitative Methodologies to Dissect Immune Cell Mechanobiology" Cells 10, no. 4: 851. https://doi.org/10.3390/cells10040851

APA Style

Pfannenstill, V., Barbotin, A., Colin-York, H., & Fritzsche, M. (2021). Quantitative Methodologies to Dissect Immune Cell Mechanobiology. Cells, 10(4), 851. https://doi.org/10.3390/cells10040851

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