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Article

Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity

1
Working Group Computational Systems Genetics (CSG), Institute of Human Genetics, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
2
Working Group Mouse Behavioral Unit (MBU), Leibniz Institute for Resilience Research (LIR), 55122 Mainz, Germany
3
Working Group Healthy Aging and Neurodegeneration, Department of Psychiatry and Psychotherapy, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Pyotr A. Slominsky
Cells 2021, 10(3), 693; https://doi.org/10.3390/cells10030693
Received: 10 February 2021 / Revised: 1 March 2021 / Accepted: 17 March 2021 / Published: 20 March 2021
(This article belongs to the Collection Advances in Neurodegenerative Disease)
Physical activity is considered a promising preventive intervention to reduce the risk of developing Alzheimer’s disease (AD). However, the positive effect of therapeutic administration of physical activity has not been proven conclusively yet, likely due to confounding factors such as varying activity regimens and life or disease stages. To examine the impact of different routines of physical activity in the early disease stages, we subjected young 5xFAD and wild-type mice to 1-day (acute) and 30-day (chronic) voluntary wheel running and compared them with age-matched sedentary controls. We observed a significant increase in brain lactate levels in acutely trained 5xFAD mice relative to all other experimental groups. Subsequent brain RNA-seq analysis did not reveal major differences in transcriptomic regulation between training durations in 5xFAD mice. In contrast, acute training yielded substantial gene expression changes in wild-type animals relative to their chronically trained and sedentary counterparts. The comparison of 5xFAD and wild-type mice showed the highest transcriptional differences in the chronic and sedentary groups, whereas acute training was associated with much fewer differentially expressed genes. In conclusion, our results suggest that different training durations did not affect the global transcriptome of 3-month-old 5xFAD mice, whereas acute running seemed to induce a similar transcriptional stress state in wild-type animals as already known for 5xFAD mice. View Full-Text
Keywords: physical activity; Alzheimer’s disease; 5xFAD; chronic; acute; wheel running physical activity; Alzheimer’s disease; 5xFAD; chronic; acute; wheel running
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MDPI and ACS Style

Wierczeiko, A.; Gammel, L.; Radyushkin, K.; Nguyen, V.T.T.; Todorov, H.; Gerber, S.; Endres, K. Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity. Cells 2021, 10, 693. https://doi.org/10.3390/cells10030693

AMA Style

Wierczeiko A, Gammel L, Radyushkin K, Nguyen VTT, Todorov H, Gerber S, Endres K. Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity. Cells. 2021; 10(3):693. https://doi.org/10.3390/cells10030693

Chicago/Turabian Style

Wierczeiko, Anna, Lena Gammel, Konstantin Radyushkin, Vu Thu Thuy Nguyen, Hristo Todorov, Susanne Gerber, and Kristina Endres. 2021. "Voluntary Wheel Running Did Not Alter Gene Expression in 5xfad Mice, but in Wild-Type Animals Exclusively after One-Day of Physical Activity" Cells 10, no. 3: 693. https://doi.org/10.3390/cells10030693

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