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Review

Towards a Framework for Better Understanding of Quiescent Cancer Cells

by
Wan Najbah Nik Nabil
1,2,†,
Zhichao Xi
1,†,
Zejia Song
1,
Lei Jin
3,
Xu Dong Zhang
4,
Hua Zhou
5,
Paul De Souza
6,
Qihan Dong
7,8,* and
Hongxi Xu
5,*
1
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2
Pharmaceutical Services Programme, Ministry of Health, Petaling Jaya 46200, Malaysia
3
School of Medicine and Public Health, The University of Newcastle, Newcastle, NSW 2308, Australia
4
School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, NSW 2308, Australia
5
Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
6
School of Medicine, Western Sydney University, Sydney, NSW 2751, Australia
7
Chinese Medicine Anti-Cancer Evaluation Program, Greg Brown Laboratory, Central Clinical School and Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia
8
Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia
*
Authors to whom correspondence should be addressed.
†
The authors contributed equally to this work.
Cells 2021, 10(3), 562; https://doi.org/10.3390/cells10030562
Submission received: 13 January 2021 / Revised: 22 February 2021 / Accepted: 2 March 2021 / Published: 5 March 2021
(This article belongs to the Section Cell Proliferation and Division)
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Abstract

Quiescent cancer cells (QCCs) are cancer cells that are reversibly suspended in G0 phase with the ability to re-enter the cell cycle and initiate tumor growth, and, ultimately, cancer recurrence and metastasis. QCCs are also therapeutically challenging due to their resistance to most conventional cancer treatments that selectively act on proliferating cells. Considering the significant impact of QCCs on cancer progression and treatment, better understanding of appropriate experimental models, and the evaluation of QCCs are key questions in the field that have direct influence on potential pharmacological interventions. Here, this review focuses on existing and emerging preclinical models and detection methods for QCCs and discusses their respective features and scope for application. By providing a framework for selecting appropriate experimental models and investigative methods, the identification of the key players that regulate the survival and activation of QCCs and the development of more effective QCC-targeting therapeutic agents may mitigate the consequences of QCCs.
Keywords: quiescence; dormancy; cancer; model; detection quiescence; dormancy; cancer; model; detection

Share and Cite

MDPI and ACS Style

Nik Nabil, W.N.; Xi, Z.; Song, Z.; Jin, L.; Zhang, X.D.; Zhou, H.; De Souza, P.; Dong, Q.; Xu, H. Towards a Framework for Better Understanding of Quiescent Cancer Cells. Cells 2021, 10, 562. https://doi.org/10.3390/cells10030562

AMA Style

Nik Nabil WN, Xi Z, Song Z, Jin L, Zhang XD, Zhou H, De Souza P, Dong Q, Xu H. Towards a Framework for Better Understanding of Quiescent Cancer Cells. Cells. 2021; 10(3):562. https://doi.org/10.3390/cells10030562

Chicago/Turabian Style

Nik Nabil, Wan Najbah, Zhichao Xi, Zejia Song, Lei Jin, Xu Dong Zhang, Hua Zhou, Paul De Souza, Qihan Dong, and Hongxi Xu. 2021. "Towards a Framework for Better Understanding of Quiescent Cancer Cells" Cells 10, no. 3: 562. https://doi.org/10.3390/cells10030562

APA Style

Nik Nabil, W. N., Xi, Z., Song, Z., Jin, L., Zhang, X. D., Zhou, H., De Souza, P., Dong, Q., & Xu, H. (2021). Towards a Framework for Better Understanding of Quiescent Cancer Cells. Cells, 10(3), 562. https://doi.org/10.3390/cells10030562

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