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Review

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

1
VIB Center for Brain & Disease Research, 3000 Leuven, Belgium
2
Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute (LBI), KU Leuven (University of Leuven), 3000 Leuven, Belgium
3
Achucarro Basque Center for Neuroscience, 48940 Leioa, Spain
4
Department of Neurosciences, Universidad del País Vasco (UPV/EHU), 48940 Leioa, Spain
5
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), 48940 Leioa, Spain
6
Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK
7
Ikerbasque Basque Foundation for Science, 48009 Bilbao, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Nadia D’Ambrosi
Cells 2021, 10(3), 540; https://doi.org/10.3390/cells10030540
Received: 27 January 2021 / Revised: 17 February 2021 / Accepted: 22 February 2021 / Published: 4 March 2021
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states. In this review, we provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease. We will also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease. View Full-Text
Keywords: astrocyte; Alzheimer´s disease; neurodegeneration; transcriptomics; RNA sequencing (RNA-seq); cellular states astrocyte; Alzheimer´s disease; neurodegeneration; transcriptomics; RNA sequencing (RNA-seq); cellular states
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MDPI and ACS Style

Preman, P.; Alfonso-Triguero, M.; Alberdi, E.; Verkhratsky, A.; Arranz, A.M. Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways. Cells 2021, 10, 540. https://doi.org/10.3390/cells10030540

AMA Style

Preman P, Alfonso-Triguero M, Alberdi E, Verkhratsky A, Arranz AM. Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways. Cells. 2021; 10(3):540. https://doi.org/10.3390/cells10030540

Chicago/Turabian Style

Preman, Pranav, Maria Alfonso-Triguero, Elena Alberdi, Alexei Verkhratsky, and Amaia M. Arranz. 2021. "Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways" Cells 10, no. 3: 540. https://doi.org/10.3390/cells10030540

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