Next Article in Journal
A LRRK2 GTP Binding Inhibitor, 68, Reduces LPS-Induced Signaling Events and TNF-α Release in Human Lymphoblasts
Previous Article in Journal
IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway
Previous Article in Special Issue
Apoptosis of Hepatocytes: Relevance for HIV-Infected Patients under Treatment
Open AccessReview

Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?

1
Programa de Pós-Graduação em Genética e Biologia Molecular, Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belém 66.075-110, Brazil
2
Programa de Pós-Graduação em Oncologia e Ciências Médicas, Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém 66.075-110, Brazil
*
Author to whom correspondence should be addressed.
Cells 2021, 10(2), 479; https://doi.org/10.3390/cells10020479
Received: 20 November 2020 / Revised: 7 December 2020 / Accepted: 11 December 2020 / Published: 23 February 2021
(This article belongs to the Special Issue Programmed Cell Death in Health and Disease)
Malaria is a parasitic disease (caused by different Plasmodium species) that affects millions of people worldwide. The lack of effective malaria drugs and a vaccine contributes to this disease, continuing to cause major public health and socioeconomic problems, especially in low-income countries. Cell death is implicated in malaria immune responses by eliminating infected cells, but it can also provoke an intense inflammatory response and lead to severe malaria outcomes. The study of the pathophysiological role of cell death in malaria in mammalians is key to understanding the parasite–host interactions and design prophylactic and therapeutic strategies for malaria. In this work, we review malaria-triggered cell death pathways (apoptosis, autophagy, necrosis, pyroptosis, NETosis, and ferroptosis) and we discuss their potential role in the development of new approaches for human malaria therapies. View Full-Text
Keywords: malaria; Plasmodium; immune response; cell death malaria; Plasmodium; immune response; cell death
Show Figures

Figure 1

MDPI and ACS Style

Sena-dos-Santos, C.; Braga-da-Silva, C.; Marques, D.; Azevedo dos Santos Pinheiro, J.; Ribeiro-dos-Santos, Â.; Cavalcante, G.C. Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? Cells 2021, 10, 479. https://doi.org/10.3390/cells10020479

AMA Style

Sena-dos-Santos C, Braga-da-Silva C, Marques D, Azevedo dos Santos Pinheiro J, Ribeiro-dos-Santos Â, Cavalcante GC. Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far? Cells. 2021; 10(2):479. https://doi.org/10.3390/cells10020479

Chicago/Turabian Style

Sena-dos-Santos, Camille; Braga-da-Silva, Cíntia; Marques, Diego; Azevedo dos Santos Pinheiro, Jhully; Ribeiro-dos-Santos, Ândrea; Cavalcante, Giovanna C. 2021. "Unraveling Cell Death Pathways during Malaria Infection: What Do We Know So Far?" Cells 10, no. 2: 479. https://doi.org/10.3390/cells10020479

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop