Next Article in Journal
The Imaging of Guard Cells of thioglucosidase (tgg) Mutants of Arabidopsis Further Links Plant Chemical Defence Systems with Physical Defence Barriers
Next Article in Special Issue
Functional Role of B Cells in Atherosclerosis
Previous Article in Journal
GSK3β, a Master Kinase in the Regulation of Adult Stem Cell Behavior
Previous Article in Special Issue
CD8+ T Cells in Atherosclerosis
 
 
Review

Inflammatory Chemokines in Atherosclerosis

by 1,†, 2,†, 1,3,4,5,‡, 1,2,3,‡ and 1,3,6,7,*,‡
1
Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, 80336 Munich, Germany
2
Department of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland
3
German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, 80336 Munich, Germany
4
Interdisciplinary Center for Clinical Research (IZKF), Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany
5
Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands
6
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, 6229 ER Maastricht, The Netherlands
7
Munich Cluster for Systems Neurology (SyNergy), 80336 Munich, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this manuscript and share first authorship.
These authors contributed equally to this manuscript and share last authorship.
Academic Editor: Guo-Chang Fan
Cells 2021, 10(2), 226; https://doi.org/10.3390/cells10020226
Received: 23 December 2020 / Revised: 18 January 2021 / Accepted: 22 January 2021 / Published: 25 January 2021
(This article belongs to the Special Issue Inflammation and Atherosclerosis)
Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the formation of occlusive or rupture-prone lesions in large arteries. Complications of atherosclerosis can become severe and lead to cardiovascular diseases (CVD) with lethal consequences. During the last three decades, chemokines and their receptors earned great attention in the research of atherosclerosis as they play a key role in development and progression of atherosclerotic lesions. They orchestrate activation, recruitment, and infiltration of immune cells and subsequent phenotypic changes, e.g., increased uptake of oxidized low-density lipoprotein (oxLDL) by macrophages, promoting the development of foam cells, a key feature developing plaques. In addition, chemokines and their receptors maintain homing of adaptive immune cells but also drive pro-atherosclerotic leukocyte responses. Recently, specific targeting, e.g., by applying cell specific knock out models have shed new light on their functions in chronic vascular inflammation. This article reviews recent findings on the role of immunomodulatory chemokines in the development of atherosclerosis and their potential for targeting. View Full-Text
Keywords: chemokines; inflammation; atherosclerosis; mouse models; chemokine receptors; cardiovascular disease chemokines; inflammation; atherosclerosis; mouse models; chemokine receptors; cardiovascular disease
Show Figures

Figure 1

MDPI and ACS Style

Gencer, S.; Evans, B.R.; van der Vorst, E.P.C.; Döring, Y.; Weber, C. Inflammatory Chemokines in Atherosclerosis. Cells 2021, 10, 226. https://doi.org/10.3390/cells10020226

AMA Style

Gencer S, Evans BR, van der Vorst EPC, Döring Y, Weber C. Inflammatory Chemokines in Atherosclerosis. Cells. 2021; 10(2):226. https://doi.org/10.3390/cells10020226

Chicago/Turabian Style

Gencer, Selin, Bryce R. Evans, Emiel P.C. van der Vorst, Yvonne Döring, and Christian Weber. 2021. "Inflammatory Chemokines in Atherosclerosis" Cells 10, no. 2: 226. https://doi.org/10.3390/cells10020226

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop