Next Article in Journal
The Role of Insulin-like Growth Factor-1 (IGF-1) in the Control of Neuroendocrine Regulation of Growth
Previous Article in Journal
The Review of Bioeffects of Static Magnetic Fields on the Oral Tissue-Derived Cells and Its Application in Regenerative Medicine
Previous Article in Special Issue
EV Cargo Sorting in Therapeutic Development for Cardiovascular Disease
Review

Role of Extracellular Vesicles in Cell Death and Inflammation

by 1 and 1,2,3,*
1
Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3083, Australia
2
The Walter and Eliza Hall Institute of Medical Research (WEHI), 1G Royal Parade, Parkville, Melbourne, VIC 3052, Australia
3
Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3010, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Francesc E. Borràs
Cells 2021, 10(10), 2663; https://doi.org/10.3390/cells10102663
Received: 9 September 2021 / Revised: 2 October 2021 / Accepted: 4 October 2021 / Published: 5 October 2021
(This article belongs to the Special Issue Extracellular Vesicles: Biogenesis, Cargo and Disease)
Extracellular vesicles (EVs) have been identified as novel mediators of intercellular communication. They work via delivering the sequestered cargo to cells in the close vicinity, as well as distant sites in the body, regulating pathophysiological processes. Cell death and inflammation are biologically crucial processes in both normal physiology and pathology. These processes are indistinguishably linked with their effectors modulating the other process. For instance, during an unresolvable infection, the upregulation of specific immune mediators leads to inflammation causing cell death and tissue damage. EVs have gained considerable interest as mediators of both cell death and inflammation during conditions, such as sepsis. This review summarizes the types of extracellular vesicles known to date and their roles in mediating immune responses leading to cell death and inflammation with specific focus on sepsis and lung inflammation. View Full-Text
Keywords: extracellular vesicles; exosomes; microvesicles; apoptotic bodies; apoptotic extracellular vesicles; cell death; inflammation; sepsis; lung inflammatory disorders; SARS-CoV-2 extracellular vesicles; exosomes; microvesicles; apoptotic bodies; apoptotic extracellular vesicles; cell death; inflammation; sepsis; lung inflammatory disorders; SARS-CoV-2
Show Figures

Figure 1

MDPI and ACS Style

Sanwlani, R.; Gangoda, L. Role of Extracellular Vesicles in Cell Death and Inflammation. Cells 2021, 10, 2663. https://doi.org/10.3390/cells10102663

AMA Style

Sanwlani R, Gangoda L. Role of Extracellular Vesicles in Cell Death and Inflammation. Cells. 2021; 10(10):2663. https://doi.org/10.3390/cells10102663

Chicago/Turabian Style

Sanwlani, Rahul, and Lahiru Gangoda. 2021. "Role of Extracellular Vesicles in Cell Death and Inflammation" Cells 10, no. 10: 2663. https://doi.org/10.3390/cells10102663

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop