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Article

Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model

1
Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University, Gangneung-si 25457, Korea
2
Department of Biomedical Science, CHA University, Seongnam-si 13488, Korea
3
Research Institute of Placental Science, CHA University, Seongnam-si 13488, Korea
4
Department of Food and Nutrition, Kyungnam University, Changwon-si 51767, Korea
5
Department of Internal Medicine, Catholic University Medical College, Seoul 03312, Korea
6
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
7
CHA Bundang Medical Center, Department of Internal Medicine, Division of Gastroenterology, CHA University School of Medicine, Seongnam-si 13496, Korea
*
Author to whom correspondence should be addressed.
These authors (J.H.C. and S.P.) contributed equally to this work.
Academic Editors: Li Xiao, Takeo Tsutsui and Alexander V. Ljubimov
Cells 2021, 10(10), 2530; https://doi.org/10.3390/cells10102530
Received: 13 August 2021 / Revised: 17 September 2021 / Accepted: 21 September 2021 / Published: 24 September 2021
(This article belongs to the Collection Chronic Inflammation, Oxidative Stress and Adult Stem Cells)
Phosphatase of regenerating liver-1 (PRL-1) controls various cellular processes and liver regeneration. However, the roles of PRL-1 in liver regeneration induced by chorionic-plate-derived mesenchymal stem cells (CP-MSCs) transplantation remain unknown. Here, we found that increased PRL-1 expression by CP-MSC transplantation enhanced liver regeneration in a bile duct ligation (BDL) rat model by promoting the migration and proliferation of hepatocytes. Engrafted CP-MSCs promoted liver function via enhanced hepatocyte proliferation through increased PRL-1 expression in vivo and in vitro. Moreover, higher increased expression of PRL-1 regulated CP-MSC migration into BDL-injured rat liver through enhancement of migration-related signals by increasing Rho family proteins. The dual effects of PRL-1 on proliferation of hepatocytes and migration of CP-MSCs were substantially reduced when PRL-1 was silenced with siRNA-PRL-1 treatment. These findings suggest that PRL-1 may serve as a multifunctional enhancer for therapeutic applications of CP-MSC transplantation. View Full-Text
Keywords: chorionic-plate-derived mesenchymal stem cells; phosphatase of regenerating liver-1; liver regeneration; bile duct ligation chorionic-plate-derived mesenchymal stem cells; phosphatase of regenerating liver-1; liver regeneration; bile duct ligation
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MDPI and ACS Style

Choi, J.H.; Park, S.; Kim, G.D.; Kim, J.Y.; Jun, J.H.; Bae, S.H.; Baik, S.K.; Hwang, S.-G.; Kim, G.J. Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model. Cells 2021, 10, 2530. https://doi.org/10.3390/cells10102530

AMA Style

Choi JH, Park S, Kim GD, Kim JY, Jun JH, Bae SH, Baik SK, Hwang S-G, Kim GJ. Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model. Cells. 2021; 10(10):2530. https://doi.org/10.3390/cells10102530

Chicago/Turabian Style

Choi, Jong H., Sohae Park, Gi D. Kim, Jae Y. Kim, Ji H. Jun, Si H. Bae, Soon K. Baik, Seong-Gyu Hwang, and Gi J. Kim. 2021. "Increased Phosphatase of Regenerating Liver-1 by Placental Stem Cells Promotes Hepatic Regeneration in a Bile-Duct-Ligated Rat Model" Cells 10, no. 10: 2530. https://doi.org/10.3390/cells10102530

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