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Review

The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Inflammation Chemokines and Immunopathology, INSERM, UMR 996, Faculté de Médecine, Université Paris-Sud, Université Paris-Saclay, 92140 Clamart, France
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Cells 2021, 10(1), 75; https://doi.org/10.3390/cells10010075
Received: 20 November 2020 / Revised: 18 December 2020 / Accepted: 30 December 2020 / Published: 5 January 2021
Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions. View Full-Text
Keywords: G protein-coupled receptor kinases (GRKs); chemokines; G protein-coupled receptors (GPCRs); atypical chemokine receptors (ACKRs); immune cell migration; chemoattractant gradients; signalling; desensitization; scaffolding G protein-coupled receptor kinases (GRKs); chemokines; G protein-coupled receptors (GPCRs); atypical chemokine receptors (ACKRs); immune cell migration; chemoattractant gradients; signalling; desensitization; scaffolding
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MDPI and ACS Style

Laganà, M.; Schlecht-Louf, G.; Bachelerie, F. The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology. Cells 2021, 10, 75. https://doi.org/10.3390/cells10010075

AMA Style

Laganà M, Schlecht-Louf G, Bachelerie F. The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology. Cells. 2021; 10(1):75. https://doi.org/10.3390/cells10010075

Chicago/Turabian Style

Laganà, Marta, Géraldine Schlecht-Louf, and Françoise Bachelerie. 2021. "The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology" Cells 10, no. 1: 75. https://doi.org/10.3390/cells10010075

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