Next Article in Journal
The Importance of Stromal Endometriosis in Thoracic Endometriosis
Next Article in Special Issue
Social Defeat Stress during Early Adolescence Confers Resilience against a Single Episode of Prolonged Stress in Adult Rats
Previous Article in Journal
Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator
Previous Article in Special Issue
Involvement of Bradykinin Receptor 2 in Nerve Growth Factor Neuroprotective Activity
Open AccessCommentary

Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production

1
Center for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music Aarhus/Aalborg, 8000 Aarhus, Denmark
2
Department of Education, Psychology, Communication, University of Bari “Aldo Moro”, 70121 Bari, Italy
3
Unit of Pharmacology, Department of Neuroscience, Faculty of Medicine, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Cells 2021, 10(1), 183; https://doi.org/10.3390/cells10010183
Received: 7 November 2020 / Revised: 24 December 2020 / Accepted: 8 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Neurotrophic Factors in Health and Disease)
Motor exercise, such as sport or musical activities, helps with a plethora of diseases by modulating brain functions in neocortical and subcortical regions, resulting in behavioural changes related to mood regulation, well-being, memory, and even cognitive preservation in aging and neurodegenerative diseases. Although evidence is accumulating on the systemic neural mechanisms mediating these brain effects, the specific mechanisms by which exercise acts upon the cellular level are still under investigation. This is particularly the case for music training, a much less studied instance of motor exercise than sport. With regards to sport, consistent neurobiological research has focused on the brain-derived neurotrophic factor (BDNF), an essential player in the central nervous system. BDNF stimulates the growth and differentiation of neurons and synapses. It thrives in the hippocampus, the cortex, and the basal forebrain, which are the areas vital for memory, learning, and higher cognitive functions. Animal models and neurocognitive experiments on human athletes converge in demonstrating that physical exercise reliably boosts BDNF levels. In this review, we highlight comparable early findings obtained with animal models and elderly humans exposed to musical stimulation, showing how perceptual exposure to music might affect BDNF release, similar to what has been observed for sport. We subsequently propose a novel hypothesis that relates the neuroplastic changes in the human brains after musical training to genetically- and exercise-driven BDNF levels. View Full-Text
Keywords: music; BDNF; BDNF gene music; BDNF; BDNF gene
Show Figures

Figure 1

MDPI and ACS Style

Brattico, E.; Bonetti, L.; Ferretti, G.; Vuust, P.; Matrone, C. Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production. Cells 2021, 10, 183. https://doi.org/10.3390/cells10010183

AMA Style

Brattico E, Bonetti L, Ferretti G, Vuust P, Matrone C. Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production. Cells. 2021; 10(1):183. https://doi.org/10.3390/cells10010183

Chicago/Turabian Style

Brattico, Elvira; Bonetti, Leonardo; Ferretti, Gabriella; Vuust, Peter; Matrone, Carmela. 2021. "Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production" Cells 10, no. 1: 183. https://doi.org/10.3390/cells10010183

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop