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The Importance of Stromal Endometriosis in Thoracic Endometriosis

1
Department of Biochemistry, University of Nairobi, Nairobi 00100, Kenya
2
Institute of Gynecology and Obstetrics, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
3
Deputy Vice Chancellor, Kirinyaga University, Kerugoya 10300, Kenya
*
Author to whom correspondence should be addressed.
Cells 2021, 10(1), 180; https://doi.org/10.3390/cells10010180
Received: 16 December 2020 / Revised: 13 January 2021 / Accepted: 13 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Molecular and Cellular Aspects of Endometriosis)
Thoracic endometriosis (TE) is a rare type of endometriosis, where endometrial tissue is found in or around the lungs and is frequent among extra-pelvic endometriosis patients. Catamenial pneumothorax (CP) is the most common form of TE and is characterized by recurrent lung collapses around menstruation. In addition to histology, immunohistochemical evaluation of endometrial implants is used more frequently. In this review, we compared immunohistochemical (CPE) with histological (CPH) characterizations of TE/CP and reevaluated arguments in favor of the implantation theory of Sampson. A summary since the first immunohistochemical description in 1998 until 2019 is provided. The emphasis was on classification of endometrial implants into glands, stroma, and both together. The most remarkable finding is the very high percentage of stromal endometriosis of 52.7% (CPE) compared to 10.2% (CPH). Chest pain, dyspnea, right-sided preference, and diaphragmatic endometrial implants showed the highest percentages in both groups. No significant association was found between the recurrence rate and the various appearances of endometriosis. Sometimes in CPE (6.8%) and CPH (30.6%) no endometrial implants were identified underlining the importance of sensitive detection of endometriosis during and after surgery. We suggest that immunohistochemical evaluation should become mandatory and will improve diagnosis and classification of the disease. View Full-Text
Keywords: endometrium; stromal endometriosis; thoracic endometriosis; Sampson; pathogenesis; endometriosis endometrium; stromal endometriosis; thoracic endometriosis; Sampson; pathogenesis; endometriosis
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MDPI and ACS Style

Mecha, E.; Makunja, R.; Maoga, J.B.; Mwaura, A.N.; Riaz, M.A.; Omwandho, C.O.A.; Meinhold-Heerlein, I.; Konrad, L. The Importance of Stromal Endometriosis in Thoracic Endometriosis. Cells 2021, 10, 180. https://doi.org/10.3390/cells10010180

AMA Style

Mecha E, Makunja R, Maoga JB, Mwaura AN, Riaz MA, Omwandho COA, Meinhold-Heerlein I, Konrad L. The Importance of Stromal Endometriosis in Thoracic Endometriosis. Cells. 2021; 10(1):180. https://doi.org/10.3390/cells10010180

Chicago/Turabian Style

Mecha, Ezekiel; Makunja, Roselydiah; Maoga, Jane B.; Mwaura, Agnes N.; Riaz, Muhammad A.; Omwandho, Charles O.A.; Meinhold-Heerlein, Ivo; Konrad, Lutz. 2021. "The Importance of Stromal Endometriosis in Thoracic Endometriosis" Cells 10, no. 1: 180. https://doi.org/10.3390/cells10010180

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