MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine
1
Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2
Laboratory of Cell Genetics and Developmental Biology, Shaanxi Normal University College of Life Sciences, Xi’an 710062, China
*
Authors to whom correspondence should be addressed.
Cells 2021, 10(1), 122; https://doi.org/10.3390/cells10010122
Received: 17 November 2020
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Revised: 22 December 2020
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Accepted: 25 December 2020
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Published: 11 January 2021
(This article belongs to the Special Issue Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease)
Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired. Repair of injury to the cell membrane is an important aspect of physiology. Inadequate membrane repair function is implicated in the pathophysiology of many human disorders. Recent studies show that Mitsugumin 53 (MG53), a TRIM family protein, plays a key role in repairing cell membrane damage and facilitating tissue regeneration. Clarifying the role of MG53 and its molecular mechanism are important for the application of MG53 in regenerative medicine. In this review, we analyze current research dissecting MG53′s function in cell membrane repair and tissue regeneration, and highlight the development of recombinant human MG53 protein as a potential therapeutic agent to repair multiple-organ injuries.
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Keywords:
TRIM protein; cell membrane repair; muscular dystrophy; myocardial infarction; acute kidney injury; acute lung injury
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MDPI and ACS Style
Li, Z.; Wang, L.; Yue, H.; Whitson, B.A.; Haggard, E.; Xu, X.; Ma, J. MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine. Cells 2021, 10, 122. https://doi.org/10.3390/cells10010122
AMA Style
Li Z, Wang L, Yue H, Whitson BA, Haggard E, Xu X, Ma J. MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine. Cells. 2021; 10(1):122. https://doi.org/10.3390/cells10010122
Chicago/Turabian StyleLi, Zhongguang, Liyang Wang, Huimin Yue, Bryan A. Whitson, Erin Haggard, Xuehong Xu, and Jianjie Ma. 2021. "MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine" Cells 10, no. 1: 122. https://doi.org/10.3390/cells10010122
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