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Open AccessArticle

The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples

1
School of Pharmacy, Nanjing Medical University, Nanjing 211166, China
2
Department of Pharmacy Intravenous Admixture Service, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
3
Tang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2017, 9(12), 653; https://doi.org/10.3390/polym9120653
Received: 20 October 2017 / Revised: 23 November 2017 / Accepted: 23 November 2017 / Published: 28 November 2017
(This article belongs to the Special Issue Molecularly Imprinted Polymers)
The feasible, reliable and selective multi-template molecularly imprinted polymers (MT-MIPs) based on SBA-15 ([email protected]) for the selective separation and determination of the trace level of ginsenoside Rb1 (Rb1), ginsenoside Rg1 (Rg1) and notoginsenoside R1 (R1) simultaneously from biological samples were developed. The polymers were constructed by SBA-15 as support, Rb1, Rg1, R1 as multi-template, acrylamide (AM) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker. The new synthetic [email protected] were satisfactorily applied to solid-phase extraction (SPE) coupled with high performance liquid chromatography (HPLC) for the separation and determination of trace Rb1, Rg1 and R1 in plasma samples. Under the optimized conditions, the limits of detection (LODs) and quantitation (LOQs) of the proposed method for Rb1, Rg1 and R1 were in the range of 0.63–0.75 ng·mL−1 and 2.1–2.5 ng·mL−1, respectively. The recoveries of R1, Rb1 and Rg1 were obtained between 93.4% and 104.3% with relative standard deviations (RSDs) in the range of 3.3–4.2%. All results show that the obtained [email protected] could be a promising prospect for the practical application in the selective separation and enrichment of trace Panax notoginseng saponins (PNS) in the biological samples. View Full-Text
Keywords: multi-template molecularly imprinted polymers; SBA-15; Panax notoginseng saponins; separation and determination; solid-phase extraction multi-template molecularly imprinted polymers; SBA-15; Panax notoginseng saponins; separation and determination; solid-phase extraction
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MDPI and ACS Style

Sun, C.; Wang, J.; Huang, J.; Yao, D.; Wang, C.-Z.; Zhang, L.; Hou, S.; Chen, L.; Yuan, C.-S. The Multi-Template Molecularly Imprinted Polymer Based on SBA-15 for Selective Separation and Determination of Panax notoginseng Saponins Simultaneously in Biological Samples. Polymers 2017, 9, 653.

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