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Polymers 2017, 9(11), 560;

Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform

Maastricht Science Programme, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
Dublin Institute of Technology, School of Chemical and Pharmaceutical Sciences, Kevin Street, D08 X622 Dublin 2, Ireland
Zuyd University of Applied Science, Faculty of Beta Sciences and Technology, Smart devices unit, Nieuw Eyckholt 300, 6419 DJ Heerlen, The Netherlands
Author to whom correspondence should be addressed.
Received: 11 October 2017 / Revised: 24 October 2017 / Accepted: 26 October 2017 / Published: 28 October 2017
(This article belongs to the Special Issue Molecularly Imprinted Polymers)
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The implementation of Molecularly Imprinted Polymers (MIPs) into sensing systems has been demonstrated abundantly over the past few decades. In this article, a novel application for an MIP-based thermal sensing platform is introduced by using the sensor to characterize the drug release kinetics of a nanoporous silver-organic framework. This Ag nanoporous matrix was loaded with acetylsalicylic acid (aspirin) which was used as a model drug compound in this study. The drug elution properties were studied by placing the nanoporous matrix in phosphate buffered saline solution for two days and measuring the drug concentration at regular time intervals. To this extent, an acrylamide-based MIP was synthesized that was able to detect aspirin in a specific and selective manner. Rebinding of the template to the MIP was analyzed using a thermal sensor platform. The results illustrate that the addition of aspirin into the sensing chamber leads to a concentration-dependent increase in the phase shift of a thermal wave that propagates through the MIP-coated sensor chip. After constructing a dose-response curve, this system was used to study the drug release kinetics of the nanoporous matrix, clearly demonstrating that the metalorganic framework releases the drug steadily over the course of the first hour, after which the concentration reaches a plateau. These findings were further confirmed by UV–Visible spectroscopy, illustrating a similar time-dependent release in the same concentration range, which demonstrates that the MIP-based platform can indeed be used as a low-cost straightforward tool to assess the efficacy of drug delivery systems in a lab environment. View Full-Text
Keywords: molecularly imprinted polymers; thermal detection; nanoporous matrix; drug delivery molecularly imprinted polymers; thermal detection; nanoporous matrix; drug delivery

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Pawley, C.J.; Perez-Gavilan, A.; Foley, K.S.; Lentink, S.; Welsh, H.N.; Tuijthof, G.; Steen Redeker, E.; Diliën, H.; Eersels, K.; Van Grinsven, B.; Cleij, T.J. Studying the Drug Delivery Kinetics of a Nanoporous Matrix Using a MIP-Based Thermal Sensing Platform. Polymers 2017, 9, 560.

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