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Polymers 2017, 9(10), 464; https://doi.org/10.3390/polym9100464

Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing

1,2,†,* , 1,†
,
1
,
1
and
1
1
College of Food Science, Sichuan Agricultural University, Yaan 625014, China
2
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
These authors contributed equally to the work.
*
Author to whom correspondence should be addressed.
Received: 7 August 2017 / Revised: 15 September 2017 / Accepted: 19 September 2017 / Published: 21 September 2017
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Abstract

Cinnamaldehyde (CA) was successfully encapsulated in β-cyclodextrin (β-CD), and polylactic acid (PLA)-based composite fibers were prepared by incorporating CA/β-CD via electrospinning. Morphological, structural, spectral, and antibacterial properties of different weight ratios of PLA:β-CD/CA (88:12, 94:6, 97:3, and 98.5:1.5) and PLA/CA/β-CD fibers were investigated. PLA and CA/β-CD were incorporated by mixing of CA/β-CD inclusions to enhance the viscosity of the mixed solution. The mechanical properties and hydrophilicity of nanofibers were improved following the addition of CA/β-CD. Moreover, CA/β-CD improved the antibacterial activities of the mixture against Escherichia coli and Staphylococcus aureus. PLA/CA/β-CD-3 exhibited excellent antibacterial effects and low cytotoxicity. Thus, our study showed that PLA/CA/β-CD fibers may have applications as wound dressing materials and for use in other biomedical applications. View Full-Text
Keywords: electrospinning; polylactic acid (PLA); cinnamaldehyde; β-cyclodextrins electrospinning; polylactic acid (PLA); cinnamaldehyde; β-cyclodextrins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Liu, Y.; Liang, X.; Zhang, R.; Lan, W.; Qin, W. Fabrication of Electrospun Polylactic Acid/Cinnamaldehyde/β-Cyclodextrin Fibers as an Antimicrobial Wound Dressing. Polymers 2017, 9, 464.

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