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Open AccessArticle

The Regulation of Osteogenesis Using Electroactive Polypyrrole Films

by Chuan Li 1,2,*, Yi-Ting Hsu 3 and Wei-Wen Hu 2,3,*
1
Department of Biomedical Engineering, Yang-Ming University, Taipei 11221, Taiwan
2
Centre for Biomedical Cell Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan
3
Department of Chemical and Materials Engineering, National Central University, Zhongli District, Taoyuan City 32001, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Changsik Song
Polymers 2016, 8(7), 258; https://doi.org/10.3390/polym8070258
Received: 24 March 2016 / Revised: 27 June 2016 / Accepted: 5 July 2016 / Published: 13 July 2016
(This article belongs to the Special Issue Conductive Polymers 2016)
To evaluate the effect of electrical conductivity of biomaterials on osteogenesis, polypyrrole (PPy) was fabricated by oxidative chemical polymerization as substrates for cell culture. Through adjusting the concentrations of monomer and initiator, polypyrrole films with different electrical conductivities were fabricated. These fabricated polypyrrole films are transparent enough for easy optical microscopy. Fourier transform infrared spectroscopy, X-ray spectroscopy and four-point probe were used to assess the microstructures, surface chemical compositions and electrical sheet resistance of films, respectively. Results indicate that higher monomer and initiator concentration leads to highly-branched PPy chains and thus promotes the electron mobility and electrical conductivity. Selected polypyrrole films then were applied for culturing rat bone marrow stromal cells. Cell viability and mineralization assays reveal that not only these films are biocompatible, but also capable of enhancing the calcium deposition into the extra cellular matrix by the differentiated cells. View Full-Text
Keywords: polypyrrole; osteogenesis; conductive polymer; electroactive; bone marrow stromal cells; mineralization polypyrrole; osteogenesis; conductive polymer; electroactive; bone marrow stromal cells; mineralization
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MDPI and ACS Style

Li, C.; Hsu, Y.-T.; Hu, W.-W. The Regulation of Osteogenesis Using Electroactive Polypyrrole Films. Polymers 2016, 8, 258.

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