Next Article in Journal
Numerical Simulation and Experimental Investigation of the Viscoelastic Heating Mechanism in Ultrasonic Plasticizing of Amorphous Polymers for Micro Injection Molding
Next Article in Special Issue
Repair Effect of Seaweed Polysaccharides with Different Contents of Sulfate Group and Molecular Weights on Damaged HK-2 Cells
Previous Article in Journal
Aerosol-Assisted Fast Formulating Uniform Pharmaceutical Polymer Microparticles with Variable Properties toward pH-Sensitive Controlled Drug Release
Previous Article in Special Issue
Study on Alginate–Chitosan Complex Formed with Different Polymers Ratio
Open AccessReview

Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery

by 1,* and 2
1
Department of internal medicine, The First Hospital in Qinhuangdao Affiliated to Hebei Medical University, Qinhuangdao 066004, China
2
Department of Chemistry, Queen’s University, Kingston, ON K7L 3N6, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Polymers 2016, 8(5), 198; https://doi.org/10.3390/polym8050198
Received: 1 March 2016 / Revised: 10 May 2016 / Accepted: 10 May 2016 / Published: 17 May 2016
(This article belongs to the Collection Polysaccharides)
Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host–guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompatible polymer. Depending on the molecular weight, PEO can be used as a plasticizer or as a toughening agent. Moreover, the hydrogels of PEO are also extensively studied because of their outstanding characteristics in biological drug delivery systems. These biomaterials based on CD and PEO for controlled drug delivery have received increasing attention in recent years. In this review, we summarize the recent progress in supramolecular architectures, focusing on poly(pseudo)rotaxanes, vesicles and supramolecular hydrogels based on CDs and PEO for drug delivery. Particular focus will be devoted to the structures and properties of supramolecular copolymers based on these materials as well as their use for the design and synthesis of supramolecular hydrogels. Moreover, the various applications of drug delivery techniques such as drug absorption, controlled release and drug targeting based CD/PEO supramolecular complexes, are also discussed. View Full-Text
Keywords: supramolecular polymers; cyclodextrins (CDs); poly(ethylene oxide); syntheses; structure; drug delivery supramolecular polymers; cyclodextrins (CDs); poly(ethylene oxide); syntheses; structure; drug delivery
Show Figures

Graphical abstract

MDPI and ACS Style

Zheng, Y.; Wyman, I.W. Supramolecular Nanostructures Based on Cyclodextrin and Poly(ethylene oxide): Syntheses, Structural Characterizations and Applications for Drug Delivery. Polymers 2016, 8, 198.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop