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Polymers
Volume 16
Issue 2
10.3390/polym16020283
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Article

The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials

by
Atsushi Tsuyukubo
,
Riku Kubota
*,
Yuzo Sato
and
Ichiro Fujimoto
Koken Research Institute, Koken Co., Ltd., 1-18-36 Takarada, Tsuruoka 997-0011, Yamagata, Japan
*
Author to whom correspondence should be addressed.
Polymers 2024, 16(2), 283; https://doi.org/10.3390/polym16020283
Submission received: 22 December 2023 / Revised: 12 January 2024 / Accepted: 17 January 2024 / Published: 19 January 2024
(This article belongs to the Special Issue Polymer Materials for Biomedical Applications)
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Abstract

A tough gel composed of atelocollagen, which lacks an immunogenetic site, is a promising material for biomedical application. In this study, we created a composite hydrogel composed of atelocollagen gel cross-linked with glutaraldehyde (GA) and poly-(N,N-dimethylacrylamide) gel exhibiting biocompatibility based on the double-network (DN) gel principle. The tensile toughness of atelocollagen gel remained constant regardless of the amount of cross-linker (GA) used. In contrast, tensile tests of the DN gel indicated that mechanical properties, such as fracture stress and toughness, were significantly higher than those of the atelocollagen gel. Moreover, fibroblast cells adhered and spread on the gels, the Schiff bases of which were treated via reductive amination for detoxification from GA. These findings demonstrate the potential of the proposed gel materials as artificial alternative materials to soft tissues with sub-MPa fracture stress.
Keywords: atelocollagen; double-network gel; toughness; soft tissue atelocollagen; double-network gel; toughness; soft tissue
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MDPI and ACS Style

Tsuyukubo, A.; Kubota, R.; Sato, Y.; Fujimoto, I. The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials. Polymers 2024, 16, 283. https://doi.org/10.3390/polym16020283

AMA Style

Tsuyukubo A, Kubota R, Sato Y, Fujimoto I. The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials. Polymers. 2024; 16(2):283. https://doi.org/10.3390/polym16020283

Chicago/Turabian Style

Tsuyukubo, Atsushi, Riku Kubota, Yuzo Sato, and Ichiro Fujimoto. 2024. "The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials" Polymers 16, no. 2: 283. https://doi.org/10.3390/polym16020283

APA Style

Tsuyukubo, A., Kubota, R., Sato, Y., & Fujimoto, I. (2024). The Toughness-Enhanced Atelocollagen Double-Network Gel for Biomaterials. Polymers, 16(2), 283. https://doi.org/10.3390/polym16020283

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