Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials and Instruments
2.2. Synthesis of Grafted Electrospun Nanofibers
2.3. Bilirubin Adsorption Experiments
2.4. Blood Compatibility Experiments
2.5. Computational Method
3. Results
3.1. Design and Theoretical Calculations
3.2. Preparation and Characterization of Three Electrospun Nanofiber Adsorbents
3.3. Bilirubin Adsorption Experiments
3.4. Blood Compatibility Test
3.5. Dynamic Bilirubin Adsorption
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Data Availability Statement
Conflicts of Interest
References
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Sample | Weight Gain (%) | Functionality (mmol g–1) |
---|---|---|
PAN-NF | -- | -- |
PAN-DA-NF | 25.30% | 1.96 |
PAN-BE-NF | 5.50% | 1.79 |
PAN-BB-NF | 19.80% | 1.82 |
PAN-BO-NF | 25.70% | 1.81 |
Isotherm Model | PAN-BE-NF | PAN-BB-NF | PAN-BO-NF |
---|---|---|---|
Langmuir isotherm | |||
qmax (mg g−1) | 818.9 | 623.8 | 536.8 |
b (L mg−1) | 0.096 | 0.07 | 0.033 |
R2 | 0.9662 | 0.9886 | 0.9561 |
Freundlich isotherm | |||
KF | 210.9 | 222.9 | 83.2 |
n | 3.91 | 5.44 | 3.07 |
R2 | 0.8452 | 0.8782 | 0.7982 |
Isotherm Model | PAN-BE-NF |
---|---|
Langmuir isotherm | |
qmax (mg g−1) | 163.7 |
b (L mg−1) | 0.012 |
R2 | 0.9868 |
Freundlich isotherm | |
KF | 14.4 |
n | 2.4 |
R2 | 0.9281 |
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Fu, X.; Shi, M.; Chen, D.; Zhao, X.; Jiang, T.; Zhao, R. Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion. Polymers 2024, 16, 1599. https://doi.org/10.3390/polym16111599
Fu X, Shi M, Chen D, Zhao X, Jiang T, Zhao R. Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion. Polymers. 2024; 16(11):1599. https://doi.org/10.3390/polym16111599
Chicago/Turabian StyleFu, Xingyu, Minsi Shi, Dingyang Chen, Xinyue Zhao, Tingting Jiang, and Rui Zhao. 2024. "Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion" Polymers 16, no. 11: 1599. https://doi.org/10.3390/polym16111599
APA StyleFu, X., Shi, M., Chen, D., Zhao, X., Jiang, T., & Zhao, R. (2024). Theory-Driven Tailoring of the Microenvironment of Quaternary Ammonium Binding Sites on Electrospun Nanofibers for Efficient Bilirubin Removal in Hemoperfusion. Polymers, 16(11), 1599. https://doi.org/10.3390/polym16111599