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Volume 15
Issue 16
10.3390/polym15163386
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Article

Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials

by
Maria V. Zykova
1,*,
Alexander B. Volikov
2,
Evgeny E. Buyko
1,
Kristina A. Bratishko
1,
Vladimir V. Ivanov
1,
Andrey I. Konstantinov
2,
Lyudmila A. Logvinova
1,
Dmitrii A. Mihalyov
1,
Nikita A. Sobolev
2,
Anastasia M. Zhirkova
2,
Sergey V. Maksimov
2,
Irina V. Perminova
2 and
Mikhail V. Belousov
1
1
Pharmaceutical Faculty, Siberian State Medical University, 634050 Tomsk, Russia
2
Department of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, 119991 Moscow, Russia
*
Author to whom correspondence should be addressed.
Polymers 2023, 15(16), 3386; https://doi.org/10.3390/polym15163386
Submission received: 31 July 2023 / Revised: 9 August 2023 / Accepted: 10 August 2023 / Published: 12 August 2023
(This article belongs to the Special Issue Polymeric Composites: Manufacturing, Processing and Applications)
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Abstract

The current article describes the biological activity of new biomaterials combining the “green” properties of humic substances (HSs) and silver nanoparticles. The aim is to investigate the antioxidant activity (AOA) of HS matrices (macroligands) and AgNPs stabilized with humic macroligands (HS-AgNPs). The unique chemical feature of HSs makes them very promising ligands (matrices) for AgNP stabilization. HSs have previously been shown to exert many pharmacological effects mediated by their AOA. AgNPs stabilized with HS showed a pronounced ability to bind to reactive oxygen species (ROS) in the test with ABTS. Also, higher AOA was observed for HS-AgNPs as compared to the HS matrices. In vitro cytotoxicity studies have shown that the stabilization of AgNPs with the HS matrices reduces the cytotoxicity of AgNPs. As a result of in vitro experiments with the use of 2,7-dichlorodihydrofluorescein diacetate (DCFDA), it was found that all HS materials tested and the HS-AgNPs did not exhibit prooxidant effects. Moreover, more pronounced AOA was shown for HS-AgNP samples as compared to the original HS matrices. Two putative mechanisms of the pronounced AOA of the tested compositions are proposed: firstly, the pronounced ability of HSs to inactivate ROS and, secondly, the large surface area and surface-to-volume ratio of HS-AgNPs, which facilitate electron transfer and mitigate kinetic barriers to the reduction reaction. As a result, the antioxidant properties of the tested HS-AgNPs might be of particular interest for biomedical applications aimed at inhibiting the growth of bacteria and viruses and the healing of purulent wounds.
Keywords: humic substances; silver nanoparticles; antioxidant activity; cytotoxicity; biomedical applications humic substances; silver nanoparticles; antioxidant activity; cytotoxicity; biomedical applications

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MDPI and ACS Style

Zykova, M.V.; Volikov, A.B.; Buyko, E.E.; Bratishko, K.A.; Ivanov, V.V.; Konstantinov, A.I.; Logvinova, L.A.; Mihalyov, D.A.; Sobolev, N.A.; Zhirkova, A.M.; et al. Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials. Polymers 2023, 15, 3386. https://doi.org/10.3390/polym15163386

AMA Style

Zykova MV, Volikov AB, Buyko EE, Bratishko KA, Ivanov VV, Konstantinov AI, Logvinova LA, Mihalyov DA, Sobolev NA, Zhirkova AM, et al. Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials. Polymers. 2023; 15(16):3386. https://doi.org/10.3390/polym15163386

Chicago/Turabian Style

Zykova, Maria V., Alexander B. Volikov, Evgeny E. Buyko, Kristina A. Bratishko, Vladimir V. Ivanov, Andrey I. Konstantinov, Lyudmila A. Logvinova, Dmitrii A. Mihalyov, Nikita A. Sobolev, Anastasia M. Zhirkova, and et al. 2023. "Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials" Polymers 15, no. 16: 3386. https://doi.org/10.3390/polym15163386

APA Style

Zykova, M. V., Volikov, A. B., Buyko, E. E., Bratishko, K. A., Ivanov, V. V., Konstantinov, A. I., Logvinova, L. A., Mihalyov, D. A., Sobolev, N. A., Zhirkova, A. M., Maksimov, S. V., Perminova, I. V., & Belousov, M. V. (2023). Enhanced Antioxidant Activity and Reduced Cytotoxicity of Silver Nanoparticles Stabilized by Different Humic Materials. Polymers, 15(16), 3386. https://doi.org/10.3390/polym15163386

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