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Article

Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne Application

1
Department of Pharmacy, Jen-Ai Hospital No. 483, Dong Rong Rd., Tali, Taichung 412, Taiwan
2
Department of Nursing, College of Nursing, Central Taiwan University of Science and Technology, 666 Buzi Rd., Beitun District, Taichung City 406, Taiwan
3
School of Pharmacy, College of Pharmacy, China Medical University, 91 Hsueh Shih Rd., Taichung 404, Taiwan
4
Department of Medical Laboratory, Chung-Kang Branch, Cheng-Ching Hospital, 966 Section 4, Taiwan Avenue, Taichung 407, Taiwan
5
Department of Medical Laboratory Science and Technology, Central Taiwan University of Science and Technology, 666 Buzi Rd., Beitun District, Taichung City 406, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Barbara Vigani
Polymers 2021, 13(4), 579; https://doi.org/10.3390/polym13040579
Received: 28 December 2020 / Revised: 8 February 2021 / Accepted: 8 February 2021 / Published: 15 February 2021
(This article belongs to the Special Issue Chitosan and Chitosan Derivatives in Biomedical Applications)
Acne is a chronic inflammatory skin disease that often occurs with anaerobic Propionibacterium acnes (P. acnes). Anti-acne patches, made of hydrocolloid or hydrogel, have become a popular way of topical treatment. The outer water-impermeable layer of commercial patches might create hypoxic conditions and promote P. acnes growth. In this study, gelatin/chitosan (GC) bilayer patches were prepared at different temperatures that included room temperature (RT), −20 °C/RT, and −80 °C/RT. The most promising GC bilayer patch (−80 °C /RT) contained a dense upper layer for protection from bacteria and infection and a porous lower layer for absorbing pus and fluids from pimples. The anti-acne bilayer patch was loaded with Cortex Phellodendri amurensis (PA) and Centella asiatica (CA) extracts. PA extract could inhibit the growth of P. acnes and CA extract was reported to improve wound healing and reduce scar formation. Moreover, the water retention rate, weight loss rate, antibacterial activity, and in vitro cytotoxicity of the patches were investigated. The porous structure of the patches promoted water retention and contributed to absorbing the exudate when used on open acne wounds. The GC bilayer patches loaded with PA/CA extracts were demonstrated to inhibit the growth of P. acnes, and accelerate the skin fibroblast cell viability. Based on their activities and characteristics, the GC bilayer patches with PA/CA extract prepared at −80 °C/RT obtain the potential for the application of acne spot treatment. View Full-Text
Keywords: anti-acne patch; gelatin; chitosan; cortex Phellodendri amurensis; Centella asiatica; Propionibacterium acnes anti-acne patch; gelatin; chitosan; cortex Phellodendri amurensis; Centella asiatica; Propionibacterium acnes
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MDPI and ACS Style

Kuo, C.-W.; Chiu, Y.-F.; Wu, M.-H.; Li, M.-H.; Wu, C.-N.; Chen, W.-S.; Huang, C.-H. Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne Application. Polymers 2021, 13, 579. https://doi.org/10.3390/polym13040579

AMA Style

Kuo C-W, Chiu Y-F, Wu M-H, Li M-H, Wu C-N, Chen W-S, Huang C-H. Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne Application. Polymers. 2021; 13(4):579. https://doi.org/10.3390/polym13040579

Chicago/Turabian Style

Kuo, Chi-Wen, Yi-Fang Chiu, Min-Hua Wu, Ming-Hsien Li, Cheng-Nan Wu, Wan-Sin Chen, and Chiung-Hua Huang. 2021. "Gelatin/Chitosan Bilayer Patches Loaded with Cortex Phellodendron amurense/Centella asiatica Extracts for Anti-Acne Application" Polymers 13, no. 4: 579. https://doi.org/10.3390/polym13040579

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