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Polymers
Volume 13
Issue 16
10.3390/polym13162812
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Article

Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing

by
Meng Zhang
1,2,3,
Dong Wang
1,2,3,
Nana Ji
1,2,3,
Shaoxiang Lee
1,2,3,*,
Guohui Wang
1,2,3,
Yuqi Zheng
1,2,3,
Xin Zhang
1,2,3,
Lin Yang
4,
Zhiwei Qin
4 and
Yang Yang
5
1
College of Environment and Safety Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
2
Shandong Engineering Research Center for Marine Environment Corrosion and Safety Protection, Qingdao University of Science and Technology, Qingdao 266042, China
3
Shandong Engineering Technology Research Center for Advanced Coating, Qingdao University of Science and Technology, Qingdao 266042, China
4
Sinochem Chemical Science and Technology Research Institute Co., Ltd., Beijing 100089, China
5
National Marine Data and Information Service, Tianjin 300171, China
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(16), 2812; https://doi.org/10.3390/polym13162812
Submission received: 20 July 2021 / Revised: 3 August 2021 / Accepted: 17 August 2021 / Published: 21 August 2021
(This article belongs to the Special Issue Hydrogel-Based Composites for Biomedical Applications)
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Abstract

Due to the spread of drug-resistant bacteria in hospitals, the development of antibacterial dressings has become a strategy to control wound infections caused by bacteria. Here, we reported a green strategy for in situ biomimetic syntheses of silver nanoparticles@organic frameworks/graphene oxide (Ag@MOF–GO) in sericin/chitosan/polyvinyl alcohol hydrogel. Ag@MOF–GO was synthesized in situ from the redox properties of tyrosine residues in silk sericin without additional chemicals, similar to a biomineralization process. The sericin/chitosan/Ag@MOF–GO dressing possessed a high porosity, good water retention, and a swelling ratio. The hemolysis rate of the composite was 3.9% and the cell viability rate was 131.2%, which indicated the hydrogel possessed good biocompatibility. The composite also showed excellent lasting antibacterial properties against drug-sensitive and drug-resistant pathogenic bacteria. The composite possessed excellent hemostatic activity. The coagulation effect of the composite may be related to its effect on the red blood cells and platelets, but it has nothing to do with the activation of coagulation factors. An in vitro cell migration assay confirmed and an in vivo evaluation of mice indicated that the composite could accelerate wound healing and re-epithelialization. In summary, the composite material is an ideal dressing for accelerating hemostasis, preventing bacterial infection, and promoting wound healing.
Keywords: biomimetic synthesis; hemostasis; antibacterial activity; wound healing biomimetic synthesis; hemostasis; antibacterial activity; wound healing

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MDPI and ACS Style

Zhang, M.; Wang, D.; Ji, N.; Lee, S.; Wang, G.; Zheng, Y.; Zhang, X.; Yang, L.; Qin, Z.; Yang, Y. Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing. Polymers 2021, 13, 2812. https://doi.org/10.3390/polym13162812

AMA Style

Zhang M, Wang D, Ji N, Lee S, Wang G, Zheng Y, Zhang X, Yang L, Qin Z, Yang Y. Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing. Polymers. 2021; 13(16):2812. https://doi.org/10.3390/polym13162812

Chicago/Turabian Style

Zhang, Meng, Dong Wang, Nana Ji, Shaoxiang Lee, Guohui Wang, Yuqi Zheng, Xin Zhang, Lin Yang, Zhiwei Qin, and Yang Yang. 2021. "Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing" Polymers 13, no. 16: 2812. https://doi.org/10.3390/polym13162812

APA Style

Zhang, M., Wang, D., Ji, N., Lee, S., Wang, G., Zheng, Y., Zhang, X., Yang, L., Qin, Z., & Yang, Y. (2021). Bioinspired Design of Sericin/Chitosan/Ag@MOF/GO Hydrogels for Efficiently Combating Resistant Bacteria, Rapid Hemostasis, and Wound Healing. Polymers, 13(16), 2812. https://doi.org/10.3390/polym13162812

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