Synergies between Surface Microstructuring and Molecular Nanopatterning for Controlling Cell Populations on Polymeric Biointerfaces
by
Andrés Díaz Lantada 1,*, Ravi Kumar 2
, Markus Guttmann 3, Markus Wissmann 3, Marc Schneider 3, Matthias Worgull 3, Stefan Hengsbach 3, Florian Rupp 3, Klaus Bade 3, Michael Hirtz 2 and Sylwia Sekula-Neuner 4
Andrés Díaz Lantada 1,*, Ravi Kumar 2, Markus Guttmann 3, Markus Wissmann 3, Marc Schneider 3, Matthias Worgull 3, Stefan Hengsbach 3, Florian Rupp 3, Klaus Bade 3, Michael Hirtz 2 and Sylwia Sekula-Neuner 4
1
Product Development Laboratory, Mechanical Engineering Department, Universidad Politécnica de Madrid; C/José Gutiérrez Abascal 2, 28006 Madrid, Spain
2
Institute of Nanotechnology (INT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
3
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
4
N.Able GmbH, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(3), 655; https://doi.org/10.3390/polym12030655
Received: 12 February 2020 / Revised: 7 March 2020 / Accepted: 9 March 2020 / Published: 13 March 2020
(This article belongs to the Section Polymer Applications)
Polymeric biointerfaces are already being used extensively in a wide set of biomedical devices and systems. The possibility of controlling cell populations on biointerfaces may be essential for connecting biological systems to synthetic materials and for researching relevant interactions between life and matter. In this study, we present and analyze synergies between an innovative approach for surface microstructuring and a molecular nanopatterning procedure of recent development. The combined set of techniques used may be instrumental for the development of a new generation of functional polymeric biointerfaces. Eukaryotic cell cultures placed upon the biointerfaces developed, both before and after molecular patterning, help to validate the proposal and to discuss the synergies between the surface microstructuring and molecular nanopatterning techniques described in the study. Their potential role in the production of versatile polymeric biointerfaces for lab- and organ-on-a-chip biodevices and towards more complex and biomimetic co-culture systems and cell cultivation set-ups are also examined.
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Keywords:
polymer microfabrication; biointerfaces; surface microstructuring; direct laser writing; electroplating; hot embossing; molecular nanopatterning; organ-on-a-chip; lab-on-a-chip
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MDPI and ACS Style
Díaz Lantada, A.; Kumar, R.; Guttmann, M.; Wissmann, M.; Schneider, M.; Worgull, M.; Hengsbach, S.; Rupp, F.; Bade, K.; Hirtz, M.; Sekula-Neuner, S. Synergies between Surface Microstructuring and Molecular Nanopatterning for Controlling Cell Populations on Polymeric Biointerfaces. Polymers 2020, 12, 655.
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