Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis and Characterization of Dendrimers
2.2. Synthesis and Characterization of Dendrimers
2.3. Self-Assembly of the Dendrimers in Water
2.4. Absorption and Emission Properties of the Self-Assemblies
2.5. Cytotoxicity and Celullar Uptake of the Self-Assemblies
3. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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T5% a (°C) | Phase Transitions b | dobs c (Å) | h k ld | XRD Parameters | |
---|---|---|---|---|---|
PAMAM16-cov-ChCou | 244 | g 25 SmA 71 e I | 46.5 | 1 0 0 | d = 46.8 Å |
23.5 | 2 0 0 | ||||
4.5 (br) | |||||
PAMAM16-ChCouf | 209 | g 21 SmA 63 e I | 46.2 | 1 0 0 | d = 46.2 Å |
23.1 | 2 0 0 | ||||
4.5 (br) | |||||
PAMAM64-cov-ChCou | 217 | g 35 Colh 87 e I | 53.3 | 1 0 0 | a = 61.5 Å |
30.8 | 1 1 0 | ||||
4.5 (br) | |||||
PAMAM64-ChCouf | 198 | g 29 Colh 81 e I | 49.3 | 1 0 0 | a = 56.7 Å |
28.2 | 1 1 0 | ||||
4.5 (br) |
CAC (μg/mL) | DhTEM (nm) a | DhDLS (nm) b | |
---|---|---|---|
PAMAM32-ChCou | 65 | 23 ± 4 | 28 ± 8 |
PAMAM64-ChCou | 46 | 30 ± 5 | 38 ± 10 |
PAMAM16-cov-ChCou | 28 | 18 ± 3 | 24 ± 6 |
PAMAM64-cov-ChCou | 19 | 40 ± 6 | 47 ± 13 |
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Concellón, A.; San Anselmo, M.; Hernández-Ainsa, S.; Romero, P.; Marcos, M.; Serrano, J.L. Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties. Polymers 2020, 12, 2872. https://doi.org/10.3390/polym12122872
Concellón A, San Anselmo M, Hernández-Ainsa S, Romero P, Marcos M, Serrano JL. Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties. Polymers. 2020; 12(12):2872. https://doi.org/10.3390/polym12122872
Chicago/Turabian StyleConcellón, Alberto, María San Anselmo, Silvia Hernández-Ainsa, Pilar Romero, Mercedes Marcos, and José Luis Serrano. 2020. "Micellar Nanocarriers from Dendritic Macromolecules Containing Fluorescent Coumarin Moieties" Polymers 12, no. 12: 2872. https://doi.org/10.3390/polym12122872