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Article

In-Vitro Biocompatibility and Hemocompatibility Study of New PET Copolyesters Intended for Heart Assist Devices

1
Faculty of Biomedical Engineering, Department of Biosensors and Processing of Biomedical Signals, Silesian University of Technology, Roosevelta 40, 41-800 Zabrze, Poland
2
Foundation of Cardiac Surgery Development, Artificial Heart Laboratory, Wolności 345a, 41-800 Zabrze, Poland
3
Faculty of Chemical Technology and Engineering, Department of Polymer and Biomaterials Science, West Pomeranian University of Technology, Al. Piastów 45, 71-311 Szczecin, Poland
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(12), 2857; https://doi.org/10.3390/polym12122857
Received: 30 October 2020 / Revised: 20 November 2020 / Accepted: 26 November 2020 / Published: 29 November 2020
(This article belongs to the Special Issue Polymeric Materials for Regenerative Medicine and Advanced Structures)
(1) Background: The evaluation of ventricular assist devices requires the usage of biocompatible and chemically stable materials. The commonly used polyurethanes are characterized by versatile properties making them well suited for heart prostheses applications, but simultaneously they show low stability in biological environments. (2) Methods: An innovative material-copolymer of poly(ethylene-terephthalate) and dimer linoleic acid—with controlled and reproducible physico-mechanical and biological properties was developed for medical applications. Biocompatibility (cytotoxicity, surface thrombogenicity, hemolysis, and biodegradation) were evaluated. All results were compared to medical grade polyurethane currently used in the extracorporeal heart prostheses. (3) Results: No cytotoxicity was observed and no significant decrease of cells density as well as no cells growth reduction was noticed. Thrombogenicity analysis showed that the investigated copolymers have the thrombogenicity potential similar to medical grade polyurethane. No hemolysis was observed (the hemolytic index was under 2% according to ASTM 756-00 standard). These new materials revealed excellent chemical stability in simulated body fluid during 180 days aging. (4) Conclusions: The biodegradation analysis showed no changes in chemical structure, molecular weight distribution, good thermal stability, and no changes in surface morphology. Investigated copolymers revealed excellent biocompatibility and great potential as materials for blood contacting devices. View Full-Text
Keywords: ventricular assist devices; polyesters; hemocompatibility; biocompatibility; PET; copolyesters; biocompatibility; thrombogenicity; hemolysis ventricular assist devices; polyesters; hemocompatibility; biocompatibility; PET; copolyesters; biocompatibility; thrombogenicity; hemolysis
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MDPI and ACS Style

Gawlikowski, M.; El Fray, M.; Janiczak, K.; Zawidlak-Węgrzyńska, B.; Kustosz, R. In-Vitro Biocompatibility and Hemocompatibility Study of New PET Copolyesters Intended for Heart Assist Devices. Polymers 2020, 12, 2857. https://doi.org/10.3390/polym12122857

AMA Style

Gawlikowski M, El Fray M, Janiczak K, Zawidlak-Węgrzyńska B, Kustosz R. In-Vitro Biocompatibility and Hemocompatibility Study of New PET Copolyesters Intended for Heart Assist Devices. Polymers. 2020; 12(12):2857. https://doi.org/10.3390/polym12122857

Chicago/Turabian Style

Gawlikowski, Maciej; El Fray, Miroslawa; Janiczak, Karolina; Zawidlak-Węgrzyńska, Barbara; Kustosz, Roman. 2020. "In-Vitro Biocompatibility and Hemocompatibility Study of New PET Copolyesters Intended for Heart Assist Devices" Polymers 12, no. 12: 2857. https://doi.org/10.3390/polym12122857

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