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Article

Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin

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Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Pharmacology Department, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Transplant Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Department of Medical Biotechnology, Tehran Medical Science, Islamic Azad University, Tehran 19395-1495, Iran
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Student Research Committee, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz 71348-14336, Iran
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Department of Polymer and Biomaterials Science, Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology, Szczecin, Al. Piastow 45, 71-311 Szczecin, Poland
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Authors to whom correspondence should be addressed.
Polymers 2020, 12(11), 2588; https://doi.org/10.3390/polym12112588
Received: 10 October 2020 / Revised: 30 October 2020 / Accepted: 31 October 2020 / Published: 4 November 2020
(This article belongs to the Special Issue Polymeric Materials for Regenerative Medicine and Advanced Structures)
Appropriate selection of suitable materials and methods is essential for scaffolds fabrication in tissue engineering. The major challenge is to mimic the structure and functions of the extracellular matrix (ECM) of the native tissues. In this study, an optimized 3D structure containing poly(3-hydroxybutyrate) (P3HB), multiwalled carbon nanotubes (MCNTs) and curcumin (CUR) was created by electrospinning a novel biomimetic scaffold. CUR, a natural anti-inflammatory compound, has been selected as a bioactive component to increase the biocompatibility and reduce the potential inflammatory reaction of electrospun scaffolds. The presence of CUR in electrospun scaffolds was confirmed by 1H NMR and Fourier-transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) revealed highly interconnected porosity of the obtained 3D structures. Addition of up to 20 wt% CUR has enhanced mechanical properties of the scaffolds. CUR has also promoted in vitro bioactivity and hydrolytic degradation of the electrospun nanofibers. The developed P3HB-MCNT composite scaffolds containing 20 wt% of CUR revealed excellent in vitro cytocompatibility using mesenchymal stem cells and in vivo biocompatibility in rat animal model study. Importantly, the reduced inflammatory reaction in the rat model after 8 weeks of implantation has also been observed for scaffolds modified with CUR. Overall, newly developed P3HB-MCNTs-CUR electrospun scaffolds have demonstrated their high potential for tissue engineering applications. View Full-Text
Keywords: P3HB; curcumin; carbon nanotubes; tissue engineering; scaffolds; electrospinning P3HB; curcumin; carbon nanotubes; tissue engineering; scaffolds; electrospinning
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MDPI and ACS Style

Tanideh, N.; Azarpira, N.; Sarafraz, N.; Zare, S.; Rowshanghiyas, A.; Farshidfar, N.; Iraji, A.; Zarei, M.; El Fray, M. Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin. Polymers 2020, 12, 2588. https://doi.org/10.3390/polym12112588

AMA Style

Tanideh N, Azarpira N, Sarafraz N, Zare S, Rowshanghiyas A, Farshidfar N, Iraji A, Zarei M, El Fray M. Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin. Polymers. 2020; 12(11):2588. https://doi.org/10.3390/polym12112588

Chicago/Turabian Style

Tanideh, Nader, Negar Azarpira, Najmeh Sarafraz, Shahrokh Zare, Aida Rowshanghiyas, Nima Farshidfar, Aida Iraji, Moein Zarei, and Miroslawa El Fray. 2020. "Poly(3-Hydroxybutyrate)-Multiwalled Carbon Nanotubes Electrospun Scaffolds Modified with Curcumin" Polymers 12, no. 11: 2588. https://doi.org/10.3390/polym12112588

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