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Review

Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications

Centre for Textile Science and Technology (2C2T), Department of Textile Engineering, University of Minho, Campus of Azurém, 4800-058 Guimarães, Portugal
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Polymers 2020, 12(1), 7; https://doi.org/10.3390/polym12010007
Received: 14 October 2019 / Revised: 21 November 2019 / Accepted: 12 December 2019 / Published: 18 December 2019
(This article belongs to the Section Polymer Processing and Engineering)
Tissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dimensional organization similar to the extracellular matrix. Various polymers can be electrospun in the form of three-dimensional scaffolds. However, very few are successfully processed using environmentally friendly solvents; poly(vinyl alcohol) (PVA) is one of those. PVA has been investigated for TE scaffolding production due to its excellent biocompatibility, biodegradability, chemo-thermal stability, mechanical performance and, most importantly, because of its ability to be dissolved in aqueous solutions. Here, a complete overview of the applications and recent advances in PVA-based electrospun nanofibrous scaffolds fabrication is provided. The most important achievements in bone, cartilage, skin, vascular, neural and corneal biomedicine, using PVA as a base substrate, are highlighted. Additionally, general concepts concerning the electrospinning technique, the stability of PVA when processed, and crosslinking alternatives to glutaraldehyde are as well reviewed. View Full-Text
Keywords: poly(vinyl alcohol); electrospun scaffolds; tissue engineering; biocompatibility; mechanical stability poly(vinyl alcohol); electrospun scaffolds; tissue engineering; biocompatibility; mechanical stability
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MDPI and ACS Style

Teixeira, M.A.; Amorim, M.T.P.; Felgueiras, H.P. Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications. Polymers 2020, 12, 7. https://doi.org/10.3390/polym12010007

AMA Style

Teixeira MA, Amorim MTP, Felgueiras HP. Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications. Polymers. 2020; 12(1):7. https://doi.org/10.3390/polym12010007

Chicago/Turabian Style

Teixeira, Marta A., M. T.P. Amorim, and Helena P. Felgueiras. 2020. "Poly(Vinyl Alcohol)-Based Nanofibrous Electrospun Scaffolds for Tissue Engineering Applications" Polymers 12, no. 1: 7. https://doi.org/10.3390/polym12010007

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