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Article

Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma

1
“Apollonia” University of Iasi, Faculty of Medical Dentistry, Department of Biomaterials, Pacurari Street, No. 11, Iasi 700511, Romania
2
NIRDBS - Institute of Biological Research Iasi, Department of Experimental and Applied Biology, Lascar Catargi 47, Iasi 700107, Romania
3
Academy of Romanian Scientists, Splaiul Independentei Street, No. 54, Bucharest 050094, Romania
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(9), 1515; https://doi.org/10.3390/polym11091515
Received: 2 August 2019 / Revised: 12 September 2019 / Accepted: 14 September 2019 / Published: 18 September 2019
(This article belongs to the Special Issue Polymeric Colloidal Systems in Nanomedicine)
More than one out of every three new cancers is a skin cancer, and the large majority are basal cell carcinomas (BCC). Targeted therapy targets the cancer’s specific genes, proteins, or tissue environment that contributes to cancer growth and survival and blocks the growth as well as the spread of cancer cells while limiting damage to healthy cells. Therefore, in the present study AS1411 aptamer-functionalized liposomes for the treatment of BCC were obtained and characterized. Aptamer conjugation increased liposome size, suggesting that the presence of an additional hydrophilic molecule on the liposomal surface increased the hydrodynamic diameter. As expected, the negatively charged DNA aptamer reduced the surface potential of the liposomes. Vertical Franz diffusion cells with artificial membranes were used to evaluate the in vitro release of 5-fluorouracil (5-FU). The aptamer moieties increase the stability of the liposomes and act as a supplementary steric barrier leading to a lower cumulative amount of the released 5-FU. The in vitro cell viability, targeting capability and apoptotic effects of liposomes on the human dermal fibroblasts and on the basal cell carcinoma TE 354.T cell lines were also evaluated. The results indicate that the functionalized liposomes are more efficient as nanocarriers than the non-functionalized ones. View Full-Text
Keywords: liposomes; drug targeting; aptamer AS1411; basal cell carcinoma liposomes; drug targeting; aptamer AS1411; basal cell carcinoma
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MDPI and ACS Style

Cadinoiu, A.N.; Rata, D.M.; Atanase, L.I.; Daraba, O.M.; Gherghel, D.; Vochita, G.; Popa, M. Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma. Polymers 2019, 11, 1515. https://doi.org/10.3390/polym11091515

AMA Style

Cadinoiu AN, Rata DM, Atanase LI, Daraba OM, Gherghel D, Vochita G, Popa M. Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma. Polymers. 2019; 11(9):1515. https://doi.org/10.3390/polym11091515

Chicago/Turabian Style

Cadinoiu, Anca N., Delia M. Rata, Leonard I. Atanase, Oana M. Daraba, Daniela Gherghel, Gabriela Vochita, and Marcel Popa. 2019. "Aptamer-Functionalized Liposomes as a Potential Treatment for Basal Cell Carcinoma" Polymers 11, no. 9: 1515. https://doi.org/10.3390/polym11091515

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