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Open AccessArticle

Large and Giant Unilamellar Vesicle(s) Obtained by Self-Assembly of Poly(dimethylsiloxane)-b-poly(ethylene oxide) Diblock Copolymers, Membrane Properties and Preliminary Investigation of their Ability to Form Hybrid Polymer/Lipid Vesicles

1
Université de Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, F-33600 Pessac, France
2
Laboratoire Léon Brillouin, UMR12 CEA-CNRS, CEA Saclay, F-91191 Gif-sur-Yvette CEDEX, France
3
Institut Charles Sadron, UPR 22 CNRS, Université de Strasbourg, 23 rue du Loess, 67034 Strasbourg, France
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(12), 2013; https://doi.org/10.3390/polym11122013
Received: 17 October 2019 / Revised: 22 November 2019 / Accepted: 2 December 2019 / Published: 4 December 2019
(This article belongs to the Special Issue Hybrid Polymer/Lipid Membranes and Thin Films)
In the emerging field of hybrid polymer/lipid vesicles, relatively few copolymers have been evaluated regarding their ability to form these structures and the resulting membrane properties have been scarcely studied. Here, we present the synthesis and self-assembly in solution of poly(dimethylsiloxane)-block-poly(ethylene oxide) diblock copolymers (PDMS-b-PEO). A library of different PDMS-b-PEO diblock copolymers was synthesized using ring-opening polymerization of hexamethylcyclotrisiloxane (D3) and further coupling with PEO chains via click chemistry. Self-assembly of the copolymers in water was studied using Dynamic Light Scattering (DLS), Static Light Scattering (SLS), Small Angle Neutron Scattering (SANS), and Cryo-Transmission Electron Microscopy (Cryo-TEM). Giant polymersomes obtained by electroformation present high toughness compared to those obtained from triblock copolymer in previous studies, for similar membrane thickness. Interestingly, these copolymers can be associated to phospholipids to form Giant Hybrid Unilamellar Vesicles (GHUV); preliminary investigations of their mechanical properties show that tough hybrid vesicles can be obtained.
Keywords: Block copolymer; Phospholipid; Giant Hybrid Unilamellar Vesicles; Micropipette; self-assembly Block copolymer; Phospholipid; Giant Hybrid Unilamellar Vesicles; Micropipette; self-assembly
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Fauquignon, M.; Ibarboure, E.; Carlotti, S.; Brûlet, A.; Schmutz, M.; Le Meins, J.-F. Large and Giant Unilamellar Vesicle(s) Obtained by Self-Assembly of Poly(dimethylsiloxane)-b-poly(ethylene oxide) Diblock Copolymers, Membrane Properties and Preliminary Investigation of their Ability to Form Hybrid Polymer/Lipid Vesicles. Polymers 2019, 11, 2013.

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