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Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer

1
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, 15771 Athens, Greece
2
Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
3
Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, Greece
4
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 ul. M. Curie-Skłodowskiej, 34, 41-819 Zabrze, Poland
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(9), 1400; https://doi.org/10.3390/polym11091400
Received: 17 July 2019 / Revised: 9 August 2019 / Accepted: 18 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Hybrid Polymer/Lipid Membranes and Thin Films)
There is an emerging need to evolve the conventional lyotropic liquid crystalline nanoparticles to advanced stimuli-responsive, therapeutic nanosystems with upgraded functionality. Towards this effort, typically used stabilizers, such as Pluronics®, can be combined or replaced by smart, stimuli-responsive block copolymers. The aim of this study is to incorporate the stimuli-responsive amphiphilic block copolymer poly(2-(dimethylamino)ethyl methacrylate)-b-poly(lauryl methacrylate) (PDMAEMA-b-PLMA) as a stabilizer in lipidic liquid crystalline nanoparticles, in order to provide steric stabilization and simultaneous stimuli-responsiveness. The physicochemical and morphological characteristics of the prepared nanosystems were investigated by light scattering techniques, cryogenic-transmission electron microscopy (cryo-TEM), X-ray diffraction (XRD) and fluorescence spectroscopy. The PDMAEMA-b-PLMA, either individually or combined with Poloxamer 407, exhibited different modes of stabilization depending on the lipid used. Due to the protonation ability of PDMAEMA blocks in acidic pH, the nanoparticles exhibited high positive charge, as well as pH-responsive charge conversion, which can be exploited towards pharmaceutical applications. The ionic strength, temperature and serum proteins influenced the physicochemical behavior of the nanoparticles, while the polymer concentration differentiated their morphology; their micropolarity and microfluidity were also evaluated. The proposed liquid crystalline nanosystems can be considered as novel and attractive pH-responsive drug and gene delivery nanocarriers due to their polycationic content. View Full-Text
Keywords: lyotropic liquid crystals; poly(2-dimethylaminoethyl methacrylate); stimuli-responsiveness; block copolymer; drug delivery nanosystems; cryo-TEM lyotropic liquid crystals; poly(2-dimethylaminoethyl methacrylate); stimuli-responsiveness; block copolymer; drug delivery nanosystems; cryo-TEM
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MDPI and ACS Style

Chountoulesi, M.; Pippa, N.; Chrysostomou, V.; Pispas, S.; Chrysina, E.D.; Forys, A.; Otulakowski, L.; Trzebicka, B.; Demetzos, C. Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer. Polymers 2019, 11, 1400. https://doi.org/10.3390/polym11091400

AMA Style

Chountoulesi M, Pippa N, Chrysostomou V, Pispas S, Chrysina ED, Forys A, Otulakowski L, Trzebicka B, Demetzos C. Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer. Polymers. 2019; 11(9):1400. https://doi.org/10.3390/polym11091400

Chicago/Turabian Style

Chountoulesi, Maria, Natassa Pippa, Varvara Chrysostomou, Stergios Pispas, Evangelia D. Chrysina, Aleksander Forys, Lukasz Otulakowski, Barbara Trzebicka, and Costas Demetzos. 2019. "Stimuli-Responsive Lyotropic Liquid Crystalline Nanosystems with Incorporated Poly(2-Dimethylamino Ethyl Methacrylate)-b-Poly(Lauryl Methacrylate) Amphiphilic Block Copolymer" Polymers 11, no. 9: 1400. https://doi.org/10.3390/polym11091400

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