Next Article in Journal
An Environmentally Sensitive Silk Fibroin/Chitosan Hydrogel and Its Drug Release Behaviors
Previous Article in Journal
One-Step Synthesis of Highly Efficient Oligo(phenylphosphonic Dihydroxypropyl Silicone Oil) Flame Retardant for Polycarbonate
Open AccessArticle

Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides

1
College of Marine Science and Biological Engineering, Qingdao University of Science & Technology, Qingdao 266042, China
2
Key Laboratory for Biochemical Engineering of Shandong Province, Qingdao 266042, China
3
Wuqiong food Co., Ltd., Raoping 515726, China
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(12), 1979; https://doi.org/10.3390/polym11121979
Received: 12 October 2019 / Revised: 12 November 2019 / Accepted: 23 November 2019 / Published: 1 December 2019
Kojic acid (KA) with antibacterial activities produced by fermentation was grafted onto konjac glucomannan oligosaccharide (KGO) composed of glucose and mannose linked by β-1,4 glycosidic bonds. A novel KGO derivative, konjac glucomannan oligosaccharide kojic acid (KGOK) possessing both moisture retention and antibacterial activities was synthesized. The structure of KGOK was characterized and analyzed by thermogravimetric analysis (TG), XRD, UV–vis absorption, FTIR, and 1H NMR. The analysis results suggest that KA was linked to the KGO molecular chain through a covalent bond, and the reaction site of KA was the methylol group. The studies demonstrate that KGOK maintained the excellent moisture absorption and retention properties of KGO and the good antibacterial activities of KA. The minimum inhibitory concentration (MIC) of KGOK is 2 mg/mL for Staphylococcus aureus, Staphylococcus epidermidis, Shewanella putrefaciens, and Salmonella enterica, while its MIC is 3 mg/mL for Escherichia coli. The multi-functionality of the KGOK synthesized from natural sources provides a theoretical foundation for their potential applications in the preservation of food, beverage, aquatic, and cosmetic products.
Keywords: konjac glucomannan oligosaccharides; kojic acid; synthesis; antibacterial; moisture retention konjac glucomannan oligosaccharides; kojic acid; synthesis; antibacterial; moisture retention
Show Figures

Graphical abstract

MDPI and ACS Style

Song, L.; Xie, W.; Zhao, Y.; Lv, X.; Yang, H.; Zeng, Q.; Zheng, Z.; Yang, X. Synthesis, Antimicrobial, Moisture Absorption and Retention Activities of Kojic Acid-Grafted Konjac Glucomannan Oligosaccharides. Polymers 2019, 11, 1979.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop