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Photocurable Bioinks for the 3D Pharming of Combination Therapies

1
Department of Bioengineering, University of California, Los Angeles, 420 Westwood Plaza, Room 5121, Engineering V, 951600 Los Angeles, CA 90095, USA
2
Division of Advanced Prosthodontics and the Weintraub Center for Reconstructive Biotechnology, University of California, 951600 Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Polymers 2018, 10(12), 1372; https://doi.org/10.3390/polym10121372
Received: 11 November 2018 / Revised: 7 December 2018 / Accepted: 10 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Additive Manufacturing of Polymeric Materials)
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Abstract

Combination therapies mediate drug synergy to improve treatment efficacy and convenience, leading to higher levels of compliance. However, there are challenges with their manufacturing as well as reduced flexibility in dosing options. This study reports on the design and characterization of a polypill fabricated through the combination of material jetting and binder jetting for the treatment of hypertension. The drugs lisinopril and spironolactone were loaded into hydrophilic hyaluronic acid and hydrophobic poly(ethylene glycol) (PEG) photocurable bioinks, respectively, and dispensed through a piezoelectric nozzle onto a blank preform tablet composed of two attachable compartments fabricated via binder jetting 3D printing. The bioinks were photopolymerized and their mechanical properties were assessed via Instron testing. Scanning electron microscopy (SEM) was performed to indicate morphological analysis. The polypill was ensembled and drug release analysis was performed. Droplet formation of bioinks loaded with hydrophilic and hydrophobic active pharmaceutical ingredients (APIs) was achieved and subsequently polymerized after a controlled dosage was dispensed onto preform tablet compartments. High-performance liquid chromatography (HPLC) analysis showed sustained release profiles for each of the loaded compounds. This study confirms the potential of material jetting in conjunction with binder jetting techniques (powder-bed 3D printing), for the production of combination therapy oral dosage forms involving both hydrophilic and hydrophobic drugs. View Full-Text
Keywords: 3D printing; pharmaceutical tablets; poly(ethylene glycol); hyaluronic acid; photopolymerization; inkjet printing 3D printing; pharmaceutical tablets; poly(ethylene glycol); hyaluronic acid; photopolymerization; inkjet printing
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Acosta-Vélez, G.F.; Linsley, C.S.; Zhu, T.Z.; Wu, W.; Wu, B.M. Photocurable Bioinks for the 3D Pharming of Combination Therapies. Polymers 2018, 10, 1372.

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