Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions
Abstract
:1. Introduction
2. Experimental
2.1. Materials
2.2. Apparatus
2.3. Preparation of SA-PAH/PBA-PAH Multilayer Films
2.4. H2O2- and Glucose-Induced Decomposition of LbL Films
2.5. Preparation of Microparticles Coated with SA-PAH/PBA-PAH Multilayer Films
2.6. H2O2- and Glucose-Induced Decomposition of Microparticles Coated with LbL Films
3. Results and Discussion
3.1. SA-PAH/PBA-PAH Multilayer Films Characterization
3.2. Preparation of Microparticles Coated with SA-PAH/PBA-PAH Multilayer Films
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Appendix A
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Glucose | pH 7.4 | pH 7.4 | pH 9.0 |
---|---|---|---|
NaCl 150 mM | NaCl 1 M | NaCl 1 M | |
1 mM | 16.9 Hz | −2.9 Hz | −18.9 Hz |
10 mM | 34.6 Hz | −8.6 Hz | −25.8 Hz |
100 mM | 43.8 Hz | 31.7 Hz | −26.8 Hz |
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Yoshida, K.; Awaji, K.; Shimizu, S.; Iwasaki, M.; Oide, Y.; Ito, M.; Dairaku, T.; Ono, T.; Kashiwagi, Y.; Sato, K. Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions. Polymers 2018, 10, 1164. https://doi.org/10.3390/polym10101164
Yoshida K, Awaji K, Shimizu S, Iwasaki M, Oide Y, Ito M, Dairaku T, Ono T, Kashiwagi Y, Sato K. Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions. Polymers. 2018; 10(10):1164. https://doi.org/10.3390/polym10101164
Chicago/Turabian StyleYoshida, Kentaro, Kazuma Awaji, Seira Shimizu, Miku Iwasaki, Yuki Oide, Megumi Ito, Takenori Dairaku, Tetsuya Ono, Yoshitomo Kashiwagi, and Katsuhiko Sato. 2018. "Preparation of Microparticles Capable of Glucose-Induced Insulin Release under Physiological Conditions" Polymers 10, no. 10: 1164. https://doi.org/10.3390/polym10101164