Next Article in Journal
Elastic Wave Propagation of Two-Dimensional Metamaterials Composed of Auxetic Star-Shaped Honeycomb Structures
Previous Article in Journal
A Combined Experiment and Crystal Plasticity FEM Study of Microstructure and Texture in Aluminium Processed by Reverse and Unidirectional Accumulative Roll-Bonding
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Crystals 2019, 9(3), 120; https://doi.org/10.3390/cryst9030120

Focusing of Microcrystals and Liquid Condensates in Acoustofluidics

1
Department of Chemical Engineering, µFlow Group, Vrije Universiteit Brussel, Brussels 1050, Belgium
2
Structural Biology Brussels, Vrije Universiteit Brussel, Brussels 1050, Belgium
*
Authors to whom correspondence should be addressed.
Received: 29 January 2019 / Revised: 20 February 2019 / Accepted: 21 February 2019 / Published: 26 February 2019
(This article belongs to the Section Biomolecular Crystals)
  |  
PDF [1740 KB, uploaded 26 February 2019]
  |     |  

Abstract

Manipulation of high-density materials, such as crystals and liquid condensates, is of great importance for many applications, including serial crystallography, structural and molecular biology, chemistry, and medicine. In this work, we describe an acoustic technique to focus and harvest flowing crystals and liquid condensates. Moreover, we show, based on numerical simulations, that the acoustic waves can be used for size-based particle (crystals, droplets, etc.) separation. This is an essential technological step in biological research, medical applications, and industrial processes. The presented technology offers high precision, biocompatibility, ease of use and additionally, is non-invasive and inexpensive. With the recent advent of X-ray Free Electron Laser (XFEL) technology and the associated enormous importance of a thin jet of crystals, this technology might pave the way to a novel type of XFEL injector. View Full-Text
Keywords: microcrystals; liquid-liquid phase separation; microfluidics; acoustic radiation; particle separation; focusing; serial crystallography; free electron laser; crystal harvesting microcrystals; liquid-liquid phase separation; microfluidics; acoustic radiation; particle separation; focusing; serial crystallography; free electron laser; crystal harvesting
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Gelin, P.; Van Lindt, J.; Bratek-Skicki, A.; Stroobants, S.; Krzek, M.; Ziemecka, I.; Tompa, P.; De Malsche, W.; Maes, D. Focusing of Microcrystals and Liquid Condensates in Acoustofluidics. Crystals 2019, 9, 120.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Crystals EISSN 2073-4352 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top