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Open AccessArticle

Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius

1
Department of Life Science, University of Seoul, Seoul 02504, Korea
2
Repigen Inc. R&D center, 17 Techno 4-ro, Yuseong-gu, Daejeon 34013, Korea
*
Author to whom correspondence should be addressed.
Crystals 2019, 9(11), 548; https://doi.org/10.3390/cryst9110548
Received: 13 August 2019 / Revised: 13 October 2019 / Accepted: 19 October 2019 / Published: 23 October 2019
(This article belongs to the Special Issue Crystallographic Studies of Enzymes)
Flavin dependent monooxygenases catalyze various reactions to play a key role in biological processes, such as catabolism, detoxification, and biosynthesis. Group D flavin dependent monooxygenases are enzymes with an Acyl-CoA dehydrogenase (ACAD) fold and use Flavin adenine dinucleotide (FAD) or Flavin mononucleotide (FMN) as a cofactor. In this research, crystal structures of Alicyclobacillus acidocaldarius protein formerly annotated as an ACAD were determined in Apo and FAD bound state. Although our structure showed high structural similarity to other ACADs, close comparison of substrate binding pocket and phylogenetic analysis showed that this protein is more closely related to other bacterial group D flavin dependent monooxygenases, such as DszC (sulfoxidase) and DnmZ and Kijd3 (nitrososynthases). View Full-Text
Keywords: flavin dependent monooxygenase; Acyl-CoA dehydrogenase; FAD flavin dependent monooxygenase; Acyl-CoA dehydrogenase; FAD
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MDPI and ACS Style

Moon, H.; Shin, S.; Choe, J. Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius. Crystals 2019, 9, 548. https://doi.org/10.3390/cryst9110548

AMA Style

Moon H, Shin S, Choe J. Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius. Crystals. 2019; 9(11):548. https://doi.org/10.3390/cryst9110548

Chicago/Turabian Style

Moon, Hyunjin; Shin, Sungwook; Choe, Jungwoo. 2019. "Crystal Structures of Putative Flavin Dependent Monooxygenase from Alicyclobacillus Acidocaldarius" Crystals 9, no. 11: 548. https://doi.org/10.3390/cryst9110548

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