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Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents

Latvian Institute of Organic Synthesis, Aizkraukles iela 21, LV-1006 Riga, Latvia
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Crystals 2020, 10(1), 37; https://doi.org/10.3390/cryst10010037
Received: 21 November 2019 / Revised: 8 January 2020 / Accepted: 13 January 2020 / Published: 15 January 2020
(This article belongs to the Section Crystalline Materials)
Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers. In this study, γ-CD/K-based MOF (γ-CD-MOF-1-α) was synthesized and its stability in various solvents was explored by single-crystal X-ray diffractometry (SCXRD) and powder X-ray diffractometry (PXRD). As a result of solvent-induced phase transformations, two novel crystalline phases of γ-CD-MOF-1 were discovered. The newly formed ε- and δ-phases crystallize in orthorhombic and tetragonal symmetry, respectively. In ε-phase, toluene was determined as a guest molecule by SCXRD. Interactions between γ-cyclodextrin and solvent molecules in ε-phase were evaluated using Hirshfeld surface analysis. The thermal stability of the new crystal forms of γ-CD-MOF-1 was analyzed by differential scanning calorimetry and thermogravimetric analysis. View Full-Text
Keywords: cyclodextrin; metal-organic framework; stability; single-crystal to single-crystal transformation; crystal structure analysis cyclodextrin; metal-organic framework; stability; single-crystal to single-crystal transformation; crystal structure analysis
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MDPI and ACS Style

Krūkle-Bērziņa, K.; Belyakov, S.; Mishnev, A.; Shubin, K. Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K+ Metal-Organic Framework in Various Solvents. Crystals 2020, 10, 37.

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