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Catalysts 2019, 9(3), 208; https://doi.org/10.3390/catal9030208

Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti

1
Department of Food, Environmental and Nutritional Sciences (DeFENS), Università degli Studi di Milano, Via Celoria 2, 20133 Milan, Italy
2
Department of Pharmaceutical Sciences (DISFARM), Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milan, Italy
3
Dipartimento di Chimica, Materiali ed Ingegneria Chimica “Giulio Natta” Politecnico di Milano, Via Mancinelli 7, I-20131 Milan, Italy
4
School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK
*
Authors to whom correspondence should be addressed.
Received: 15 January 2019 / Revised: 1 February 2019 / Accepted: 12 February 2019 / Published: 26 February 2019
(This article belongs to the Special Issue Flow Biocatalysis)
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Abstract

Enantiomerically enriched 2-hydroxymethylalkanoic acids were prepared by oxidative desymmetrisation of achiral 1,3-diols using immobilized cells of Acetobacter aceti in water at 28 °C. The biotransformations were first performed in batch mode with cells immobilized in dry alginate, furnishing the desired products with high molar conversion and reaction times ranging from 2 to 6 h. The biocatalytic process was intensified using a multiphasic flow reactor, where a segmented gas–liquid flow regime was applied for achieving an efficient O2-liquid transfer; the continuous flow systems allowed for high yields and high biocatalyst productivity. View Full-Text
Keywords: oxidation; whole cells; immobilization; biocatalysis; flow reactor; reactor design oxidation; whole cells; immobilization; biocatalysis; flow reactor; reactor design
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De Vitis, V.; Dall’Oglio, F.; Tentori, F.; Contente, M.L.; Romano, D.; Brenna, E.; Tamborini, L.; Molinari, F. Bioprocess Intensification Using Flow Reactors: Stereoselective Oxidation of Achiral 1,3-diols with Immobilized Acetobacter Aceti. Catalysts 2019, 9, 208.

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