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Open AccessFeature PaperReview

Bioproduction of Isoprenoids and Other Secondary Metabolites Using Methanotrophic Bacteria as an Alternative Microbial Cell Factory Option: Current Stage and Future Aspects

Department of Chemical Engineering, Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Korea
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Catalysts 2019, 9(11), 883; https://doi.org/10.3390/catal9110883
Received: 28 September 2019 / Revised: 19 October 2019 / Accepted: 21 October 2019 / Published: 24 October 2019
(This article belongs to the Special Issue Biocatalytic Applications in Biotechnology)
Methane is a promising carbon feedstock for industrial biomanufacturing because of its low price and high abundance. Recent advances in metabolic engineering and systems biology in methanotrophs have made it possible to produce a variety of value-added compounds from methane, including secondary metabolites. Isoprenoids are one of the largest family of secondary metabolites and have many useful industrial applications. In this review, we highlight the current efforts invested to methanotrophs for the production of isoprenoids and other secondary metabolites, including riboflavin and ectoine. The future outlook for improving secondary metabolites production (especially of isoprenoids) using metabolic engineering of methanotrophs is also discussed. View Full-Text
Keywords: methane; methanotrophs; secondary metabolites; isoprenoid; metabolic engineering methane; methanotrophs; secondary metabolites; isoprenoid; metabolic engineering
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Jeon, Y.C.; Nguyen, A.D.; Lee, E.Y. Bioproduction of Isoprenoids and Other Secondary Metabolites Using Methanotrophic Bacteria as an Alternative Microbial Cell Factory Option: Current Stage and Future Aspects. Catalysts 2019, 9, 883.

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