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Rh(III)-Catalyzed C–H Bond Activation for the Construction of Heterocycles with sp3-Carbon Centers

by Run Wang 1,2,†, Xiong Xie 1,2,†, Hong Liu 1,2 and Yu Zhou 1,2,*
1
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China
2
School of Pharmacy, University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
The authors contribute equally.
Catalysts 2019, 9(10), 823; https://doi.org/10.3390/catal9100823
Received: 21 August 2019 / Revised: 25 September 2019 / Accepted: 25 September 2019 / Published: 30 September 2019
(This article belongs to the Special Issue Catalysts for C–H Activation and Functionalisation)
Rh(III)-catalyzed C–H activation features mild reaction conditions, good functional group tolerance, high reaction efficiency, and regioselectivity. Recently, it has attracted tremendous attention and has been employed to synthesize various heterocycles, such as indoles, isoquinolines, isoquinolones, pyrroles, pyridines, and polyheterocycles, which are important privileged structures in biological molecules, natural products, and agrochemicals. In this short review, we attempt to present an overview of recent advances in Rh(III)-mediated C–H bond activation to generate diverse heterocyclic scaffolds with sp3 carbon centers. View Full-Text
Keywords: C–H bond activation; Rhodium(III)-based catalysts; heterocycle with sp3 carbon centers; chirality C–H bond activation; Rhodium(III)-based catalysts; heterocycle with sp3 carbon centers; chirality
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MDPI and ACS Style

Wang, R.; Xie, X.; Liu, H.; Zhou, Y. Rh(III)-Catalyzed C–H Bond Activation for the Construction of Heterocycles with sp3-Carbon Centers. Catalysts 2019, 9, 823.

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