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Catalysts 2018, 8(8), 335; https://doi.org/10.3390/catal8080335

From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose

1
Univ. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d’Opale, EA7394–ICV-Institut Charles Viollette, F-59000 Lille, France
2
Univ. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F-59000 Lille, France
3
IFP Energies Nouvelles, Rond-point de l’échangeur de Solaize, BP 3, 69360 Solaize, France
4
IFP Energies Nouvelles, 1 et 4 avenue de Bois-Préau, 92852 Rueil Malmaison, France
*
Author to whom correspondence should be addressed.
Received: 13 July 2018 / Revised: 23 July 2018 / Accepted: 27 July 2018 / Published: 17 August 2018
(This article belongs to the Special Issue Catalytic Methods in Flow Chemistry)
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Abstract

Notably available from the cellulose contained in lignocellulosic biomass, glucose is a highly attractive substrate for eco-efficient processes towards high-value chemicals. A recent strategy for biomass valorization consists on combining biocatalysis and chemocatalysis to realise the so-called chemo-enzymatic or hybrid catalysis. Optimisation of the glucose conversion to 5-hydroxymethylfurfural (HMF) is the object of many research efforts. HMF can be produced by chemo-catalyzed fructose dehydration, while fructose can be selectively obtained from enzymatic glucose isomerization. Despite recent advances in HMF production, a fully integrated efficient process remains to be demonstrated. Our innovative approach consists on a continuous process involving enzymatic glucose isomerization, selective arylboronic-acid mediated fructose complexation/transportation, and chemical fructose dehydration to HMF. We designed a novel reactor based on two aqueous phases dynamically connected via an organic liquid membrane, which enabled substantial enhancement of glucose conversion (70%) while avoiding intermediate separation steps. Furthermore, in the as-combined steps, the use of an immobilized glucose isomerase and an acidic resin facilitates catalyst recycling. View Full-Text
Keywords: (bio) catalysis; biomass; glucose; 5-hydroxymethylfurfural (HMF); chemo-enzymatic catalysis (bio) catalysis; biomass; glucose; 5-hydroxymethylfurfural (HMF); chemo-enzymatic catalysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Gimbernat, A.; Guehl, M.; Lopes Ferreira, N.; Heuson, E.; Dhulster, P.; Capron, M.; Dumeignil, F.; Delcroix, D.; Girardon, J.-S.; Froidevaux, R. From a Sequential Chemo-Enzymatic Approach to a Continuous Process for HMF Production from Glucose. Catalysts 2018, 8, 335.

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