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Article

Concatenated Batch and Continuous Flow Procedures for the Upgrading of Glycerol-Derived Aminodiols via N-Acetylation and Acetalization Reactions

Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca’ Foscari, Via Torino 155, 30172 Venezia, Italy
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Catalysts 2021, 11(1), 21; https://doi.org/10.3390/catal11010021
Received: 1 December 2020 / Revised: 21 December 2020 / Accepted: 24 December 2020 / Published: 27 December 2020
(This article belongs to the Special Issue Continuous-Flow Catalysis)
An unprecedented two-step sequence was designed by combining batch and continuous flow (CF) protocols for the upgrading of two aminodiol regioisomers derived from glycerol, i.e., 3-amino-1,2-propanediol and 2-amino-1,3-propanediol (serinol). Under batch conditions, at 80–90 °C, both substrates were quantitatively converted into the corresponding amides through a catalyst-free N-acetylation reaction mediated by an innocuous enol ester as isopropenyl acetate (iPAc). Thereafter, at 30–100 °C and 1–10 atm, the amide derivatives underwent a selective CF-acetalisation in the presence of acetone and a solid acid catalyst, to afford the double-functionalized (amide-acetal) products. View Full-Text
Keywords: isopropenyl acetate; aminodiols; N-acetylation; acetalization isopropenyl acetate; aminodiols; N-acetylation; acetalization
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MDPI and ACS Style

Rigo, D.; Carmo Dos Santos, N.A.; Perosa, A.; Selva, M. Concatenated Batch and Continuous Flow Procedures for the Upgrading of Glycerol-Derived Aminodiols via N-Acetylation and Acetalization Reactions. Catalysts 2021, 11, 21. https://doi.org/10.3390/catal11010021

AMA Style

Rigo D, Carmo Dos Santos NA, Perosa A, Selva M. Concatenated Batch and Continuous Flow Procedures for the Upgrading of Glycerol-Derived Aminodiols via N-Acetylation and Acetalization Reactions. Catalysts. 2021; 11(1):21. https://doi.org/10.3390/catal11010021

Chicago/Turabian Style

Rigo, Davide, Nadia A. Carmo Dos Santos, Alvise Perosa, and Maurizio Selva. 2021. "Concatenated Batch and Continuous Flow Procedures for the Upgrading of Glycerol-Derived Aminodiols via N-Acetylation and Acetalization Reactions" Catalysts 11, no. 1: 21. https://doi.org/10.3390/catal11010021

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